Cornea - ARVO

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ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - CorneaResults: Median right and left eye investigator grades were 2.0 andinterquartile ranges were 0.5 and 1.0 respectively. There were nodifferences between eyes (Wilcoxon matched pairs p=0.30). Anumber of image processing metrics were significantly associatedwith LWE grade: these included area, convexity and staining regionthickness (Spearman rho all at least 0.61, all p
ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - CorneaPurpose: Previous studies indicate that single lens replacements ortime of day do not influence end of day (EOD) contact lens comfort,suggesting that length of wear may be a driving factor in ocularcomfort. This study investigated the impact of lens-free intervals ofvarying lengths on EOD comfort.Methods: 25 symptomatic lens wearers (comfortable wear time6.3±1.6hrs) participated in this randomised, cross-over studyinvolving nine individual 12-hour days: 1 lens-free (spectaclewearing) assessment day and 8 lens wear days. On each lens wearday, lenses were worn bilaterally in 2-hour intervals, separated bylens-free (recovery) intervals of 0, 30, 60 or 80 minutes (repeatedthroughout the day). For each 2-hour lens wear interval, a new pair oflenses was worn. Ocular comfort was rated before and after the firstlens insertion, and after each 2-hour lens interval, using a 0-100visual analogue scale (0= extremely uncomfortable and 100 = verycomfortable). This study involved 2 different types of siliconehydrogel lenses, and the order of lens type and length of recoveryperiod was randomised. Participants were unaware of the true studypurpose and that a new lens pair was used for each lens wear interval.Results: A continuous decrease in comfort with wearing time wasobserved on all lens wear days, independent of recovery periods orlens type. There were no differences in EOD comfort scores betweenlens wear days for lens 1 (Mean range 48.9±17.8 to 56.0±19.8,p>0.42) or lens 2 (Mean range 53.7±15.9 to 58.8±13.9, p>0.9), andratings were significantly lower compared to the lens-free assessmentday (70.8±16.2) (p
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Cornea - ARVO

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