Cornea - ARVO

ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - Corneaconjunctiva or ocular surface anomalies were found. In group a arealoss of meibomian gland was evaluated from 41% to 59%. Density ofglands was low. In group b area loss of meibomian gland wasevaluated from 10% to 42%. In younger children (4 to 7 yo) densityof glands was tight and lenght size shorter.Conclusions: In children, few data are known about MeibomianGland development and function. Our study is suitable in childrenwith dry eye for the evaluation of Meibomian Glands and can be auseful tool. A larger study has to be performed for a betterunderstanding of dry eye ocular surface impairment in children.Commercial Relationships: Dominique Bremond-Gignac, None;Solange Milazzo, NoneProgram Number: 567 Poster Board Number: B0204Presentation Time: 10:30 AM - 12:15 PMGender differences in ocular biometric datayoona jang 1 , Hiroshi Uozato 1, 2 , Takushi Kawamorita 1, 2 , YukoShibata 3 . 1 Department of Visual Science, Kitasato UniversityGraduate School, Sagamihara, Japan; 2 Ophthoptics and VisualSciences, Kitasato University School of Allied Health Science,Sagamihara, Japan; 3 Ophthalmology and Visual Sciences, KitasatoUniversity Graduate School, Sagamihara, Japan.Purpose: To compare the differences in ocular biometric data withregard to genderMethods: Seventy-two eyes from 38 healthy subjects (mean age =21.4 ± 2.7 years, range: 18 to 31 years) including 19 males (mean age= 22.5 ± 2.6 years) and 19 females (mean age = 20.3 ± 2.5 years)were recruited. Anterior chamber depth (ACD) and axial length (AL)were measured with IOL Master TM (Carl Zeiss Meditec, Jena,Germany). ACD was defined as the length between the center ofanterior surface of cornea and the center of anterior lens surface.Angle lambda (kappa), distance from central pupillary eccentricity tothinnest corneal thickness, corneal curvature(CR), cornealpower(CP), central corneal thickness(CCT) were measured withpachymetry with a dual scheimpflug imaging system Galilei TM(Ziemer Ophthalmic Systems, Port, Switzerland ). The statisticalsignificance of the gender differences between measurements wasevaluated by Student’s t-test.Results: The mean ACD was 3.77 ± 0.32 mm for males and 3.65 ±0.25 mm for females. Males had significantly deeper ACD thanfemales (p = 0.049). The mean angle lambda, AL and CCT were 3.15± 1.60 °, 25.31 ± 1.59 mm, 552.01 ± 30.05 μm for males and 3.86 ±1.58 °, 24.79 ± 1.15 mm, 551.81 ± 20.23 μm for females,respectively. Males had significantly larger angle lambda thanfemales (p = 0.028). There was no statistically significant differencein the AL and distance from central pupillary eccentricity to thinnestcorneal thickness in gender comparison, but there are tendencyassociated with differences gender (p = 0.056, p = 0.054). There wasno statistically significant difference in mean CR, CP and CCTbetween males and females.Conclusions: Both ACD and angle lambda had statisticallysignificant difference with gender. And, AL and distance from centralpupillary eccentricity to thinnest corneal thickness were tendencyassociated with gender difference. However, gender did not show anystatistically significant effect on cornea as CR, CP and CCT.Therefore, consider to gender would be an important factor to ocularbiometric examinations for refractive and cataract surgeries.Commercial Relationships: yoona jang, None; Hiroshi Uozato,None; Takushi Kawamorita, None; Yuko Shibata, None138 Dry Eye and Lacrimal Gland ISunday, May 05, 2013 1:00 PM-2:45 PMExhibit Hall Poster SessionProgram #/Board # Range: 900-954/B0205-B0259Organizing Section: CorneaProgram Number: 900 Poster Board Number: B0205Presentation Time: 1:00 PM - 2:45 PMDoes Altering the Volume of an Artificial Tear Applied to theEye Influence Vision?William H. Ridder, Monisha Paripatyadar, Lisa Wahl. Basic &Visual Science, Southern California College of Optometry, Fullerton,CA.Purpose: Artificial tears (AT) are the most common treatment fordry eye. Several studies have shown that immediately after an AT isplaced on the eye vision is degraded for a short time. The purpose ofthis investigation was to determine if there is a correlation betweenthe volume of AT placed on the eye and the degradation in vision.Methods: Six normal, adult subjects took part in this project. Snellenacuity was better than 20/25 in the eye tested. The subjects had 1hour of training with the contrast sensitivity (CS) measurementtechnique before data collection. CS to a 14 cpd sine wave grating(16 ms stimulus presented at 1 sec after the blink) was continuallytracked (using a 2 AFC technique) before and after (minimum of 25minutes) an AT (Refresh Optive, Allergan, Inc.) was applied. Thevolumes of the ATs applied, randomized across visits, were 25, 45, or65 µl (Pos D Pipette, Rainin Inst.). The data for different dropvolumes were collected on separate days. The magnitude of the lossin normalized contrast sensitivity was compared across dropvolumes.Results: The average loss in normalized CS (mean ± SD) for thedrop volumes were: 0.46 ± 0.182, 0.50 ± 0.171, and 0.60 ± 0.293 for25, 45, and 65 µl, respectively. A paired t-test found a significantdifference in the CS loss between the 25 and 65 µl drop sizes (p =0.05, t = 2.46). No other comparisons were significant (p > 0.05).Conclusions: The CS decreased as the volume of the applied ATincreased. This may be the result of a greater disruption in the tearlayer as the AT drop volume increases.Commercial Relationships: William H. Ridder, None; MonishaParipatyadar, None; Lisa Wahl, NoneProgram Number: 901 Poster Board Number: B0206Presentation Time: 1:00 PM - 2:45 PMEffects of Omega-3 Fatty Acid and Hyaluronic acid Mixture EyeDrops on the Ocular Surface in Desiccating Stress inducedMurine Dry EyeZhengri Li 1 , Jung-Han Choi 2 , Hyo Seok Lee 3 , Ji-Suk Choi 4 , Han JinOh 5 , Kyung Chul Yoon 6 . 1 Chonnam National Uinversity and hospital,Gwangju, Republic of Korea; 2 Chonnam National Uinversity andhospital, Gwangju, Republic of Korea; 3 Chonnam NationalUinversity and hospital, Gwangju, Republic of Korea; 4 ChonnamNational Uinversity and hospital, Gwangju, Republic of Korea;5 Chonnam National Uinversity and hospital, Gwangju, Republic ofKorea; 6 Chonnam National Uinversity and hospital, Gwangju,Republic of Korea.Purpose: To investigate the effects of topical application of omega-3Fatty Acid (FA) and hyaluronic acid (HA) mixtures on inflammationand oxidative stress markers in a mouse model of experimental dryeye (EDE).Methods: Eye drops consisting of 0.02%, or 0.2% omega-3 FA and0.1% HA mixtures, or 0.1% HA were applied in desiccating stressinduced murine dry eye. Corneal irregularity and corneal fluoresceinstaining scores were measured at 5 and 10 days after treatment.Levels of interleukin (IL)-1β, IL-17, and interferon gamma-inducedprotein (IP)-10 were measured in the conjunctiva using a multiplex©2013, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permissionto reproduce any abstract, contact the ARVO Office at arvo@arvo.org.