Cornea - ARVO

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ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - Corneaobtained in the suspension containing riboflavin and 1% fluorescein.Conclusions: Fluorescein absorbs UV-A in a significant andconcentration-depending manner. The addition of fluorescein led to asignificant reduction in the killing-rate of S. aureus in vitro. Ourresults indicate that fluorescein competes riboflavin for theabsorption of UV-A during CXL, limiting the therapeutic effect. Inconsequence, preoperative staining of the ulcus or infiltrate at the slitlampusing fluorescein must be avoided prior to CXL, since it maysignificantly reduce the therapeutic effect of CXL.Commercial Relationships: Farhad Hafezi, Schwind (F), Ziemer(F), PCT/CH 2012/000090 (P); Zisis Gatzioufas, None; ArthurHammer, None; David Tabibian, None; Olivier Richoz, NoneProgram Number: 5269 Poster Board Number: C0188Presentation Time: 2:45 PM - 4:30 PMIn Vivo Ultrasound-enhanced Penetration Of Topical RiboflavinInto The Corneal StromaRicardo Lamy, Elliot Chan, Hui Zhang, Vasant Salgaonkar, Chris J.Diederich, Jay M. Stewart. Ophthalmology, University of California,San Francisco, San Francisco, CA.Purpose: To determine whether ultrasound treatment can promotethe permeation of topical riboflavin into the corneal stroma in vivo.Methods: New Zealand white rabbits were used for the study.Treated eyes had a cup with riboflavin 0.1% placed over the centralcornea and were treated with ultrasound 1 W/cm2 at 880 Khz for 6minutes followed by the removal of the cup and the application oftwo drops of riboflavin solution every 3 minutes for 39 minutes. Inthe control eyes (no ultrasound) two drops of riboflavin solution wereapplied every 3 minutes for 45 minutes. Animals were thensacrificed, corneas were excised, and confocal microscopy wasperformed to detect the presence of riboflavin in the cornea.Results: Fluorescence intensity was significantly higher in the treatedcorneas (P
ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - CorneaBella, None; José Ignacio Fernández-Vigo, None; Jose M. Benitezdel-Castillo,NoneSupport: None in the Support field belowProgram Number: 5272 Poster Board Number: C0191Presentation Time: 2:45 PM - 4:30 PMCorneal Deformation Characteristics and IOP before and afterCollagen CrosslinkingCynthia J. Roberts, Ashraf M. Mahmoud, Richard G. Lembach,Thomas F. Mauger. Department of Ophthalmology and Departmentof Biomedical Engineering, The Ohio State University, Columbus,OH.Purpose: To evaluate in vivo corneal deformation characteristics andmeasures of intraocular pressure (IOP) before and after cornealcollagen crosslinking (CXL).Methods: 26 eyes of 26 subjects with keratoconus or post-refractivesurgery ectasia had CXL treatment (Tx), and had pre and 6 monthpost CXL data from Goldmann Applanation Tonometry (GAT),PASCAL Dynamic Contour Tonometry (DCT), Ocularl ResponseAnalyzer (ORA) for Goldman-correlated IOPg, corneal compensatedIOPcc, corneal hysteresis, CH and corneal resistance factor, CRF, aswell as CorVis ST, for inward (T1) and outward (T2) applanationtimes, pachymetry (pach), and inward (Vin) velocity. 16 fellow eyeswho had data from the same devices at the same times were controls(C). Custom software for ORA produced pressures at inward (P1)and outward (P2) applanations, applanation times (Time1,Time2),maximum pressure, (Pmax) and time, (Tpmax). Custom software forCorVis image edges produced radius of curvature at highestconcavity, (rad-curveHC) and time, (TimeHC). Data were comparedwith t-tests.Results: Significant differences between Tx and C groups werefound in IOPg (Tx: +1.2±2.2mmHg; C: -1.1±1.4mmHg; p=.0004),IOPcc (Tx: +1.4±3.5mmHg; C: -1.3±1.9mmHg; p=.0020), P1(Tx:+7.5±17.3mmHg; C: -5.8±15.3mmHg; p=.0155), P2(Tx:+10.8±20.7mmHg; C: -8.3±10.9mmHg; p=.0003), Pmax (Tx:+25.4±59.6mmHg; C: -8.6±24.2mmHg.0138; p=), Tpmax (Tx:+.24±.74ms; C: -.11±.29ms.0375; ), Time1(Tx: +.17±.36ms; C: -.13±1.9ms; p=.0085), Pach(Tx: -71±52µ; C: -21±44µ; p=.0029), andVin(Tx: -.005±.063ms; C: +.035±.039ms; p=.0301). In the ORA, thedifference in pre to post-CXL Time2 minus Time1 was significant inC (+.21±.32ms; p=.0161), but not in Tx. In the CorVis, the differencein pre to post-CXL T2-T1, was significant in Tx(-1.11±.99ms;p0.05). UCVA (-0.09 logmar units) and BCVA (-0.07 logmarunits) improved statistically (p
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