Cornea - ARVO

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ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - CorneaPresentation Time: 2:45 PM - 4:30 PMCorneal Endothelial Cell Density Following TransepithelialCollagen Cross-LinkingMichael W. Raciti 1 , Randy J. Epstein 1, 2 , Parag Majmudar 1, 2 , WilliamTrattler 3 . 1 Rush University Medical Center, Chicago, IL; 2 ChicagoCornea Consultants, Chicago, IL; 3 Center For Excellence In EyeCare, Miami, FL.Purpose: To evaluate the change in corneal endothelial cell densityafter transepithelial collagen cross-linking (CXL) for the treatment ofcorneal ectasia.Methods: Transepithelial CXL was performed using riboflavin 0.1%followed by UV-A light for 30 minutes in patients with keratoconus,pellucid degeneration, or LASIK-induced ectasia. Only eyes withcorneal thickness greater than or equal to 400µm were treated.Endothelial cell counts were measured pre-CXL and at least 6 monthspost-CXL using noncontact specular microscopy.Results: Seventy three eyes were evaluated. The mean cornealendothelial cell density was 2522 +/- 513 cells/mm2 pre-CXL and2674 +/- 452 cells/mm2 post-CXL (P=0.063).Conclusions: This study showed no significant change in cornealendothelial cell density after transepithelial CXL byriboflavin/ultraviolet-A treatment for corneal ectasia.Commercial Relationships: Michael W. Raciti, None; Randy J.Epstein, alcon (C), bausch and lomb (C), tear science (C); ParagMajmudar, None; William Trattler, CXLO (I), CXLUSA (C),CURVERIGHT (I)Program Number: 5264 Poster Board Number: C0183Presentation Time: 2:45 PM - 4:30 PMConcurrent vs Sequential Corneal Collagen Crosslinking andIntacs® for Keratoconus and Corneal EctasiaSteven A. Greenstein 1, 2 , Peter S. Hersh 2, 1 . 1 Ophthalmology, UMDNJ- New Jersey Medical School, Newark, NJ; 2 Cornea and Laser EyeInstitute - Hersh Vision Group, Teaneck, NJ.Purpose: To determine the effect of concurrent vs sequential cornealcollagen crosslinking (CXL) and Intacs® on visual and topographicoutcomes in patients with keratoconus (kc) and corneal ectasia.Methods: 41 eyes with KC and ectasia were analyzed in aprospective randomized control clinical trial. All patients wereinitially treated with symmetric 350µm Intacs® segments (AdditionTechnology Inc, Illinois, USA). Following this Intacs® procedurepatients were randomized into 2 groups. 1 group received standardCXL immediately following the Intacs® procedure (concurrentgroup, n=23), and the second group received the identical CXLtreatment 3 months after the initial Intacs® procedure (sequentialgroup, n=18). All outcomes were analyzed 1 year after CXL therapy.The outcomes analyzed included uncorrected (UCVA) and bestcorrected (BCVA) visual acuity, and maximum (Kmax), flat (Kf),steep (Ks), and average (Kavg) keratometry as measured by thePentacam (Oculus Inc, Wetzlar, Germany).Results: Visually, UCVA significantly improved from logMAR0.96±0.31 to 0.82±0.31 (p=0.03), and 1.03±0.19 to 0.85±0.31(p=0.01), and BCVA changed from 0.36±0.17 to 0.34±0.21, and0.29±0.23 to 0.21±0.15, in the concurrent and sequential grouprespectively; although these latter changes were not statisticallysignificant (pconcurrent=0.7, psequential=0.06). Topographically, inthe concurrent group, Kmax, Kavg, Kf, Ks, changed from 61.9±8.2Dto 61.0±7.8D (p=0.15), 51.5±5.2D to 50.1±5.0D (p
ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - CorneaCommercial Relationships: David Tabibian, None; OlivierRichoz, None; Eberhard Spoerl, None; Arthur Hammer, None;Florence Hoogewoud, None; Farhad Hafezi, Schwind (F), Ziemer(F), PCT/CH 2012/000090 (P)Program Number: 5266 Poster Board Number: C0185Presentation Time: 2:45 PM - 4:30 PMCorneal collagen crosslinking in young patients: One-year resultsMarcony R. Santhiago 2, 1 , Mario L. Monteiro 1 , Haroldo Moraes 1 ,Rodrigo Espindola 1 , Ramon C. Ghanem 1 , Marcelo Netto 1 .1 Ophthalmology, Federal University of Rio de Janeiro, Rio deJaneiro, Brazil; 2 Cataract and Refractive Surgery - Ophthalmology,Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.Purpose: To analyze one-year outcomes of epithelium-off cornealcollagen crosslinking (CXL) in young patients (
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Cornea - ARVO

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