Cornea - ARVO

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ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - Corneastudied, the majority (> 50%) had negligible or no OBL, and 20%less than 10% of the total flap area. The remaining had OBL to up of20% of the total flap area. In all cases the flap was ‘delayed’, that isdeveloping in areas already processed by the femtosecond laser, thusnot interfering with the flap creation.Conclusions: Τhis highly accurate, novel validation digital techniqueconfirms the high reproducibility in flap dimensions and smalloccurrence of OBL in both myopic and hyperopic LASIK cases withthe FS200 femtosecond laser.Commercial Relationships: Ioanna Kontari, None; GeorgeAsimellis, None; A. John Kanellopoulos, Alcon Laboratories, Inc.(C), Avedro (C), Bausch and Lomb (C), Ocular Therapeutix (C)Program Number: 3110 Poster Board Number: D0045Presentation Time: 8:30 AM - 10:15 AMThe effect of procedure room temperature and humidity onLASIK outcomesMichael I. Seider 1 , Stephen D. McLeod 1 , Travis Porco 1 , Steven C.Schallhorn 1, 2 . 1 Ophthalmology, University of California, SanFrancisco, San Francisco, CA; 2 Optical Express, Inc., Glasgow,United Kingdom.Purpose: To determine if procedure room temperature and humidityduring LASIK affects refractive outcomes in a very large patientsample.Methods: Patients aged 18 to 75 years old who underwent LASIK atan Optical Express, Inc. location in their United Kingdom and Irelandcenters from January 1, 2008 to June 30, 2011 who met inclusioncriteria (including post-operative refractive goal of plano) wereincluded. Patient age, gender, pre- and one month post-LASIKmanifest refraction and flap creation technique were recorded as wellas the ambient temperature and humidity during LASIK. Effect sizedetermination, in addition to univariate and multivariate analysis wasperformed to characterize the relationships between LASIKprocedure room temperature and humidity and post-operativerefractive outcome.Results: 202,394 eyes of 105,712 patients were included. Whenconsidering all eyes in our population, an increase of one degreeCelsius during LASIK was associated with a 0.003 diopter morehyperopic refraction one month post-operatively (P=0.0094) and anincrease in one percent humidity was associated with a 0.0004 moremyopic refraction (P0.05). The central K values decrease by a mean of1.35 ± 3.1 and 0.41 ± 3.5 respectively (p
ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - CorneaYishan Qian. Ophthalmology, Eye and ENT hospital FudanUniversity, Shanghai, China.Purpose: To investigate the characteristics of corneal epithelialpachymetry map in patients wearing orthokeratology lens (OK lens)using the automatically segmentation function of SD-OCT.Methods: 60 patients who had been fitted with myopic OK lens forat least one night were included in the study (mean age, 10.6±2.38years) and 11 patients without any history of contact lens served ascontrols. Patients were divided into 6 groups according to theduration of orthokeratology lens wearing. An SD-OCT (RTVue SD-OCT, Optovue, Inc, CA) with a pachymetry module was used tomeasure the central 6mm corneal epithelial topography. Theepithelial thickness of the central 3 mm, the average thickness of the3 to 5mm ring (Peripheral 1, P1), and the average thickness of the 5to 6mm ring (Peripheral 2, P2) were recorded and compared withinindividual groups. Munnerlyn’s formula was used to model theexpected change in refractive error based on measured changes intopographical corneal epithelial thickness.Results: The epithelial thickness of the central cornea wassignificantly reduced in all ortho-k groups. Except for group one, nosignificantly difference in the epithelial thickness of 3 to 5mm (P1)was found between the ortho-k group and the control one. For P2, theepithelial thickness increased in group2 to 5, but only group 3reached significant level. The refractive change predicted byMunnerlyn’s formula based on changes in topographical cornealepithelial thickness was much less than the measured refractivechanges found in all groups.Conclusions: Epithelial pachymetry map automatically generated bythe SD OCT could provide object and comprehensive information ofepithelial change caused by overnight wearing of OK lens. OK lenscan cause significant thinning of central corneal epithelium andthickening of midperipheral corneal epithelium. Changes induced byovernight orthokeratology can not be wholly explained by theinduced changes in corneal epithelial thickness. Change in stromalthickness or the bending of the corneal tissue may also play a role.Presentation Time: 8:30 AM - 10:15 AMPatient Satisfaction and Quality of Vision after Wavefrontguided(WFG) vs. Wavefront-optimized (WFO) LASIKRose K. Sia 1 , Richard D. Stutzman 2 , Joseph F. Pasternak 2 , Denise S.Ryan 1 , Jennifer B. Eaddy 1 , Lorie A. Logan 1 , Lamarr Peppers 1 ,Edward W. Trudo 1 , Kraig S. Bower 3 . 1 US Army WarfighterRefractive Surg Research Ctr, Fort Belvoir Community Hospital, FortBelvoir, VA; 2 Ophthalmology, Walter Reed National MilitaryMedical Center, Bethesda, MD; 3 The Wilmer Eye Institute, JohnsHopkins University, Baltimore, MD.Purpose: To compare higher order aberration (HOA) root meansquare (RMS) and patient satisfaction of postoperative vision afterWFG vs. WFO LASIK.Methods: Participants randomized to receive WFG LASIK (VISXStar S4, Abbott Medical Optics) or WFO LASIK (WavelightAllegretto Wave Eye-Q, Alcon Surgical) underwent testing todetermine their HOA RMS preoperatively and at 6 months (M)postoperatively. RMS HOA were analyzed at four different pupilsizes (4, 5, 6, and 7mm) using Complete Ophthalmic AnalysisSystem (COAS, Abbott Medical Optics). A repeated measuresanalysis of variance (RM-ANOVA) was used to compare WFG vs.WFO LASIK HOA RMS at each pupil size over time. Participantsresponded to a questionnaire preoperatively and 6M postoperatively.A Mann-Whitney test was used to compare patient satisfaction ofpostoperative vision. A p-value
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