lomocycline 250mg - Lomus Pharmaceuticals Pvt. Ltd.

LOMOCYCLINE CapsuleDosage Forms/CompositionCapsule: Each capsule contains Tetracycline 200mg/500mgPharmacological IndexBroad spectrum AntibioticINDICATIONDental: Treatment of periodontitis associated with presence of Actinobacillusactinomycetemcomitans (AA). As adjunctive therapy in recurrent aphthous ulcers.Medical: Treatment of susceptible bacterial infections of both gram-positive and gramnegativeorganisms; also infections due to Mycoplasma, Chlamydia, and Rickettsia;indicated for acne, exacerbations of chronic bronchitis, and treatment of gonorrhea andsyphilis in patients that are allergic to penicillin; used concomitantly withmetronidazole, bismuth subsalicylate and an H2-antagonist for the treatment ofduodenal ulcer disease induced by H. pylori.Pregnancy Risk FactorDContraindicationsHypersensitivity to tetracycline or any component; do not administer to children lessthan or equal to 8 years of age.Warnings/PrecautionsUse of tetracyclines during tooth development may cause permanent discoloration ofthe teeth and enamel, hypoplasia and retardation of skeletal development and bonegrowth with risk being the greatest for children 10%: Gastrointestinal: Discoloration of teeth and enamel hypoplasia (young children).1% to 10%:Dermatologic: Photosensitivity.Gastrointestinal: Nausea, diarrhea.

hepatotoxicity, thrombophlebitis, paresthesia, acute renal failure, azotemia, renaldamage, superinfections, anaphylaxis, hypersensitivity reactions, candidalsuperinfection .Overdosage/ToxicologySymptoms of overdose include nausea, anorexia, diarrhea; following GIdecontamination. Supportive care only.Drug InteractionsDecreased effect: Calcium-, magnesium-, or aluminum-containing antacids, oralcontraceptives, iron, zinc, sodium bicarbonate, penicillins, cimetidine may decreasetetracycline absorption.Although no clinical evidence exists, may bind with bismuth or calcium carbonate, anexcipient in bismuth subsalicylate, during treatment for H. pylori.Increased toxicity: Methoxyflurane anesthesia when concurrent with tetracycline maycause fatal nephrotoxicity; warfarin with tetracyclines may result in increasedanticoagulation; tetracyclines may rarely increase digoxin serum levels.Mechanism of ActionInhibits bacterial protein synthesis by binding with the 30S and possibly the 50Sribosomal subunit(s) of susceptible bacteria; may also cause alterations in thecytoplasmic membrane.Pharmacodynamics/KineticsAbsorption: Oral: 75%Distribution: Small amount appears in bileRelative diffusion of antimicrobial agents from blood into cerebrospinal fluid (CSF):Good only with inflammation (exceeds usual MICs)Ratio of CSF to blood level (%): Inflamed meninges: 25Protein binding: 20% to 60%Half-life:Normal renal function: 8-11 hoursEnd-stage renal disease: 57-108 hoursTime to peak serum concentration: Oral: Within 2-4 hoursElimination: Primary route is the kidney, with 60% of a dose excreted as unchangeddrug in the urine; concentrated by liver in bile and feces in biologically active formUsual DosageTetracycline should be taken either one hour before meals or two hours after meals.The maximum dose should not exceed 3 g daily. The usual dose depending on theseverity of the infection is: Adults and children of 12 years and older: 250 - 500 mgevery 6 hours.Patient InformationTake this medication exactly as directed. Take all of the prescription even if you see animprovement in your condition. Do not use more or more often than recommended.Pregnancy/breast-feeding precautions: Do not get pregnant while taking thismedication - effectiveness of oral contraceptives may be reduced; use appropriate

arrier contraceptive measures. Breast-feeding is not recommended.LOMUS Drug Information CenterLomus Pharmaceuticals Pvt. Ltd.P.O. Box No 4506, Lomus House (Corporate office),Kailash Chour, Lazimpat, Kathmandu, NepalPh: 4436396 (Hunting Line). Fx: 977-1-4436395E-mail: druginfo@lomus.com.np