Click here for full resume - College of Engineering - The University ...

The University of Tennessee Medical Center, Knoxville, TennesseeCookeville Regional Medical Center, Cookeville, TennesseePROFESSIONAL SOCIETIES:The American Physical SocietyThe International Society for Neutron Capture TherapyThe American College of Physicians, elected a Fellow, 2004The Wilderness Medical SocietyFRATERNAL SOCIETY:Phi Chi National Medical FraternityHONORS AND AWARDS:Eagle Scout 1968National Honor Society 1971National Merit Scholarship Honorable Mention 1972Sigma Pi Sigma National Physics Honor Society, Chapter President 1978-1979, ChapterVice-President 1976-1977, Chapter Secretary 1973-1976Fellowship to the Neils Bohr Institutet Copenhagen, Denmark, 1979-1980 as a graduatestudent in physics to study theoretical nuclear physicsAlpha Epsilon Delta (premedical honor society), 1982 Scholarship WinnerAppointed as a student member of the Academic Affairs Committee of The University ofTennessee Board of Trustees, 1984-1985 and 1985-1986National Institutes of Health Medical Student Research Fellow, 1984&1985Board of Councillors, International Society for Neutron Capture Therapy, 2000-2006Fellow of the American College of Physicians, 2004STUDENT RESEARCH SUPPORT:Research Fellow in Theoretical Nuclear Physics, Grant from the Danish ResearchCouncil Niels Bohr Institutet, University of Copenhagen, Blegdamsvej 17 DK-2100, Copenhagen 0, Denmark, 1979 through 1980.National Institutes of Health Medical Student Research Fellow awarded twice for optionquarters I & II at the University of Tennessee Center for the Health Sciences,summers of 1983 & 1984 during the first and second years of medical school.PRESENT POSITIONS:Clinical Assistant Professor of Medicine, Graduate School of Medicine, The Universityof Tennessee Medical Center, Knoxville, TennesseeAdjunct Associate Professor, Department of Nuclear and Radiological Engineering, TheUniversity of Tennessee, Knoxville, TennesseeResearch Staff, Oak Ridge National Laboratory, Oak Ridge, TennesseeTEACHING EXPERIENCE:3

Graduate Teaching Assistant, Department of Physics and Astronomy, The University ofTennessee, Knoxville, 1978-1982Teaching Medicine Residents and Attending on the Teaching Service, The GraduateSchool of Medicine, The University of Tennessee, Knoxville, 1992-2003Wilderness Medical Society Course, Townsend, Tennessee 2006 & 2007Advanced Cardiac Life Support (ACLS) 2005-PresentNuclear Engineering 567, Medical Physics, 2004Nurse Practioner Mentor, intermittently 1998-2007University of Kansas medical students at Philmont Scout Ranch, Cimarron, New Mexico,2005 and 2006OTHER PERTINENT EXPERIENCE:Computer Analyst with Q clearance, Computer Science Division, X-10, Oak RidgeNational Laboratory, Oak Ridge, Tennessee 37831-6266, 1980 to 1981President of the Founding Board, University Physicians Association, Inc., 1993 to 1995;President, 1995 to 1998; Board Member 1993 to 1999; Medical Director, 1998 to1999Board Member, Bioneutrics, Inc., 9821 Cogdill Road, Suite 1, Knoxville, Tennessee37932, 1996 to 2003Board Member, Volunteer Research Group, 1924 Alcoa Highway, Knoxville, Tennessee37920, 1998 to 1999Board of Councilors, International Society for Neutron Capture Therapy, 2000 to 2006Advanced Cardiac Life Support (ACLS) InstructorAdvanced Stroke Life Support (ASLS) InstructorEMPLOYMENT:1976-1979 Graduate Teaching AssistantDepartment of PhysicsThe University of TennesseeKnoxville, Tennessee 379961979-1980 Research Fellow in Theoretical Nuclear PhysicsNiels Bohr InstitutetUniversity of CopenhagenBlegdamsvej 17DK-2100 Copenhagen 0, Denmark1980-1982 Research AssistantshipDepartment of PhysicsThe University of TennesseeKnoxville, Tennessee1980-1981 Computer AnalystComputer Science Division, X-10Oak Ridge National LaboratoryOak Ridge, Tennessee6-9/1984 National Institutes of Health Medical Student Research FellowThe University of Tennessee Center for the Health SciencesMemphis, Tennessee4

6-9/1985 National Institutes of Health Medical Student Research FellowThe University of Tennessee Center for the Health SciencesMemphis, Tennessee1985-1986 Extern Methodist HospitalMemphis, Tennessee1986-1987 Internship in Internal MedicineThe University of Tennessee Medical CenterKnoxville, Tennessee 379201987-1989 Residency in Internal MedicineThe University of Tennessee Medical CenterKnoxville, Tennessee 379201989-1992 Private InternistInternal Medicine AssociatesSt. Mary’s HospitalEmerald AvenueKnoxville, Tennessee1992-1999 Assistant Professor of MedicineThe Graduate School of MedicineThe University of Tennessee Medical CenterKnoxville, Tennessee 379201993-2003 Senior member of Internal Medicine of KnoxvilleThe University of Tennessee Medical CenterSuite 560, 1932 Alcoa HighwayKnoxville, Tennessee 379961998-1999 Medical director for the University Physicians Association1932 Alcoa HighwayKnoxville, Tennessee 379201999-2003 Assistant Professor of RadiologyThe Graduate School of MedicineThe University of Tennessee Medical CenterKnoxville, Tennessee 379202003- Clinical Assistant Professor of MedicinePresentThe Graduate School of MedicineThe University of Tennessee Medical CenterKnoxville, Tennessee 379202003- Hospitalist2009 Knoxville Inpatient PhysiciansThe University of Tennessee Medical CenterKnoxville, Tennessee 379202004- Adjunct Assistant ProfessorPresentDepartment of Radiological and Nuclear EngineeringThe University of TennesseeKnoxville, Tennessee 379962009- Oak Ridge National LaboratoryPresent Research StaffPO Box 2008 MS60755

Building 5800, Room G208Oak Ridge, Tennessee 37831-60756

PUBLICATIONS:1. “Anisotropic Effects in Dilute Pt-Mn: A Nuclear Orientation Study”, J. R. Thompson,J. O. Thomson, P. G. Huray, S. E. Nave, and T. L. Nichols, J. Phys. F: Metal Phy., 8, No. 1(1978).2. “Heavy-Ion Two-Neutron Transfer Reactions in Deformed Nuclei”, M. W. Guidry, T.L. Nichols, R. E. Neese, J. O. Rasmussen, L. Oliviera, R. Donangelo, and D. Habs, InvitedPaper for the Sven Gosta Nilsson Memorial Issue, Nuc. Phys., A361, 275 (1981).3. “Inelastic Scattering and Transfer Reactions using very Heavy Ions”, M. W. Guidry, R.E. Neese, and T. L. Nichols, Contemporary Research in Nuclear Physics, (Plenum Press, 1982),pp. 193-222.4. “Heavy-Ion Transfer Reactions as a Unique Probe of Quantal Many-Body Systems”, M.W. Guidry and T. L. Nichols, Phys. Rev. C., 25(1), 1982, pp.689-692.5. “Frequency Content of the Electrocardiogram. Spatial Features and Effects ofMyocardial Infarction”, T. L. Nichols and D. M. Mirvis, Journal of Electrocardiology 18(2),1985, pp. 185-194.6. “Determination of Cardiac Equivalent Generator Properties Using a NumericalExpansion Method”, T. L. Nichols, M. A. Lawson, and D. M. Mirvis, Journal ofElectrocardiology 20(5), pp. 352-356, 1987.7. “The Use of Positron Emission Tomography in Treatment Planning for Boron NeutronCapture Therapy: A Clinical Perspective.”, T. L. Nichols, G. W. Kabalka, G. T. Smith, D.Longford, E. Buonocore, and K. F. Hübner, Clinical Physiology, p255, 18:3, 1998.9. “The Role of Dynamic Positron Emission Tomography for Quantifying Boron-10 InVivoUsing the Fructose Complex F-18 Labeled Boronophenylalanine PET”. G. W. Kabalka, G. T.Smith, T. L. Nichols, J. P. Dyke, D. Longford, and K. F. Hübner, Frontiers in Neutron CaptureTherapy, Hawthorne, M. F. And Wiersma, R. M. (Eds), Plenum Press, New York, 1508 pages(July 1, 2001), Plenum Pub Corp; ISBN: 030646442X.10. “Treatment Planning Based on Dynamic Positron Emission Tomography for BoronNeutron Capture Therapy for Glioblastoma Multiforme.”, Trent L. Nichols, George W. Kabalka,Gary T. Smith, Jon P. Dyke, C. P. D. Longford, Karl F. Hübner, Frontiers in Neutron CaptureTherapy, Hawthorne, M. F. and Wiersma, R. M. (Eds), Plenum Press, New York, 1508 pages(July 1, 2001) Plenum Pub Corp; ISBN: 030646442X.11. Kabalka, G. W.; Srivastava, R. R.; Das, B.C.; Nichols, T. L.; Smith, G. T. “TheDevelopment of Boron Neutron Capture Agents Utilizing Positron Emission Tomography,” inContemporary Boron Chemistry, Hughes, A.K.; Davidson, M. (Eds.) Royal Society ofChemistry, Cambridge, United Kingdom, 2000, p120.7

12. Nichols, T. L.; Kabalka, G. W.; Miller, L. F.; Khan, M.; Wyatt, M.; Smith, G. T.;Longford, C.P.D. “Improved Treatment Planning for Boron Neutron Capture Therapy forGlioblastoma Multiforme Using Fluorine-18 Labelled para-Boronophenylalanine and PositronEmission Tomography”, Med. Phys., Vol. 29, Issue 10, pp2351-2358, 2002.13. Kabalka, G. W.; Nichols, T. L.; Smith, G. T.; Miller, L.F.; Khan, M. K., and Busse, P.M. “The use of positron emission tomography to develop boron neutron capture therapytreatment plans for Metastatic Malignant Melanoma”, Journal of Neuro-Oncology, 62: 187-195,2003.14. T. L. Nichols, L. F. Miller, G. W. Kabalka, “The Microdosimetry of Boron NeutronCapture Therapy in a Randomised Ellipsoidal Cell Geometry”, Radiation Protection Dosimetry,116, 1-4 Pt 2, pp466-469, 2005.15. T. L. Nichols, L. F. Miller, G. W. Kabalka, and T. M. Dudney, “Microdosimetric Studyfor Interpretation of Outcomes from Boron Neutron Capture Therapy Clinical Trials”, RadiationProtection Dosimetry, (2007) 126(1-4): pp. 645-647.16. Slaybaugh, R.N.; Azmy, Y. Y.; Williams, M. L.; Langer, M. P.; Kirk, B. L.; Peplow, D.E.; Ilas, D.; and Nichols, T. L., “Radiation Treatment Planning Using Discrete OrdinatesCodes”, Transactions of the American Nuclear Society, (2007), 96, pp. 343-345.17. Trent L. Nichols, George W. Kabalka, Laurence F. Miller, Michael T. McCormack , andAndrew Johnson , “Implications for Clinical Treatment from the Micrometer Site DosimetricCalculations in of Boron Neutron Capture Therapy”, Applied Radiation and Isotopes, 67(2009)S161-S163.8

Longford, E. Buonocore, and K. F. Hübner, Symposium on Clinical Physics, Helsinki, 12-13June 1998.12. “F-18 Labeled Boronophenylalanine PET for Dosimetry and Treatment Planning inBoron Neutron Capture Therapy (BNCT)”, G. T. SmithThe Society of Nuclear Medicine 45thAnnual Meeting, Toronto, Canada, 11-17 June 1998.13. “Boron Neutron Capture Therapy: A ‘New’ Cancer Treatment.”, Trent L. Nichols,George W. Kabalka, Gary T. Smith, Karl F. Hübner, C.P.D. Longford, invited talk to theUniversity of Tennessee MBA program for Physician Executives in Medicine, 6 July 1998.14. “The Role of Dynamic Positron Emission Tomography for Quantifying Boron-10 In VivoUsing the Fructose Complex F-18 Labeled Boronophenylalanine PET”. G.W.Kabalka,G.T.Smith, T.L.Nichols, J.P.Dyke, D.Longford, and K.F.Hübner, Eighth InternationalSymposium on Neutron Capture Therapy for Cancer, International Society for Neutron CaptureTherapy, LaJolla, California 13-18 September 1998.15. “Treatment Planning Based on Dynamic Positron Emission Tomography for BoronNeutron Capture Therapy for Glioblastoma Multiforme.” Trent L. Nichols, George W. Kabalka,Gary T. Smith, Jon P. Dyke, C.P.D. Longford, Karl F. Hübner, Eighth International Symposiumon Neutron Capture Therapy for Cancer, International Society for Neutron Capture Therapy,LaJolla, California 13-18 September 1998.16. “Positron Emission Tomography for Dosimetry in Boron Neutron Capture Therapy”,Trent Nichols, George Kabalka, Gary Smith, Karl Hübner, Centennial Meeting of the AmericanPhysical Society, Atlanta, GA., March 1999.17. “The First Use of 18 F-para-Boronophenylalanine to Image Metastatic MalignantMelanoma with Positron Emission Tomography”, Trent L. Nichols, George W. Kabalka, Gary T.Smith, and Karl F. Hubner, Second Tennessee Conference on Biomedical Engineering atVanderbilt University, Nashville, Tennessee, 9-11 April 1999.18. “The Use of Positron Emission Tomography for Dosimetry in Treatment Planning forBoron Neutron Capture Therapy: A Clinical Perspective”, Trent Nichols, George Kabalka, GarySmith, Karl Hübner, invited talk at Brookhaven National Laboratory 22 April 1999.19. “Use of PET to Improve Dosimetery for BNCT.” L. F. Miller, G. W. Kabalka, T. L.Nichols. American Nuclear Society 1999 Annual Meeting, Boston, MA (June, 1999).20. “The Development of Boron Neutron Capture Agents Utilizing Positron EmissionTomography”, G. W. Kabalka, R. Srivastava, B. C. Das, T. L. Nichols, G. T. Smith, I.M.E.Boronmeeting in Durham, United Kingdom, July 1999.21. "The Development of Boron Neutron Capture Agents Utilizing Positron EmissionTomography" G. W. Kabalka, R. R. Srivastava, B. C. Das, T. L. Nichols, G. T. Smith. ACSSoutheastern Regional Meeting. Knoxville, TN (October 1999).10

22. “The use of 18 F-para-Boronophenylalanine in treatment planning for boron neutroncapture therapy.”, TL Nichols, invited talk at the Massachusetts Institute of Technology,December 1999.23. “The Synthesis of Carbon-11 and Fluorine-18 Labeled para-Boronophenylalanine andTheir Use in PET-based Treatment planning for Boron Neutron Capture Therapy.”, GWKabalka, TL Nichols, M Akula, CP Longford, and LF Miller, Fourth Annual Research Day, TheUniversity of Tennessee Medical Center, Knoxville (May 2000).24. “The First Use of 18 F-para-Boronophenylalanine to Image Metastatic MalignantMelanoma with Positron Emission Tomography.”, TL Nichols, GW Kabalka, PM Busse, GTSmith, LW Miller, MK Khan, and CPD Longford, Fourth Annual Research Day, The Universityof Tennessee Medical Center, Knoxville (May 2000).25. "Determination of Tissue Specific Kinetics to Improve Boron Neutron Capture Therapy."L. F. Miller, G. W. Kabalka, M. Khan, A. Rahim, T. Nichols, J. Thie, G. T. Smith. AnnualMeeting of the Health Physics Society, Denver, CO (June, 2000).26. "Synthesis of Carbon-11 and Fluroine-18 Labeled para-Boronophenylalanine and TheirUse in PET -Based Treatment Planning for Boron Neutron Capture Therapy." G. W. Kabalka,T. L. Nichols, C.P.D. Longford, G. T. Smith, International Isotope Meeting, Dresden Germany(June, 2000).27. "Identification of Biokinetic Parameters for Boron Neutron Capture Therapy". L. F.Miller, G. W. Kabalka, M. Khan, A. Rahim, and T. Nichols. Proceedings of the AmericanNuclear Society and Health Physics Society Conference on Radiation Protection for OurNational Priorities: Medicine, The Environment and the Legacy, Spokane, Washington(September, 2000).28. "Use of Radiolabeled Positron Emission Tomography to Improve Dosimetery for BoronNeutron Capture Therapy." M. K. Kahn, L. F. Miller, G. W. Kabalka and T. L. Nichols,Radiation Protection and Shielding Annual Meeting, Spokane, Washington (September, 2000).29. "The Development and Preliminary Testing of New Boronated Agents for BNCT Basedon PET Derived Data" T. L. Nichols, G. W. Kabalka, M. Kahn, B. Das, S. Das, L. Miller. TheNinth International Symposium on Neutron Capture Therapy for Cancer. Osaka, Japan (October,2000).30. "The Use of Positron Emission Tomography in BNCT Treatment Planning for MetastaticMalignant Melanoma and Glioblastoma Multiforme" G. W. Kabalka, T. Nichols, G. Smith, L.Miller and M. Kahn. The Ninth International Symposium on Neutron Capture Therapy forCancer. Osaka, Japan (October, 2000).31. "Use of Positron Emission Tomography for Determination of Tissue Specific Kinetics."L. F. Miller, G. Kabalka, M. Khan, A. Rhim, T. Nichols, M. Wyatt, J. Thie, G. Smith, and I.11

Apostoaei. The Ninth International Symposium on Neutron Capture Therapy for Cancer. Osaka,Japan (October, 2000).32. "Positron Emission Tomography Based Dosimetry for Boron Neutron Capture Therapy."L. F. Miller, M. K. Khan, G. W. Kabalka, T. L. Nichols, G. T. Smith, A. Rahim, M. S. Wyatt, A.I. Apostoaei, C. A. Large, National Meeting of the American Nuclear Society, Washington,D.C., November, 2000.33. “The Clinical Course of Five Patients who had Boron Neutron Capture FollowingPositron Emission Tomography with 18 F-para-Boronophenylalanine”, T. L. Nichols, L. F.Miller, M. K. Khan, G. W. Kabalka, G. T. Smith, and M. S. Wyatt, National Meeting of theAmerican Nuclear Society, Washington, D.C., November, 2000.34. “Boron Neutron Capture Therapy: Practice and Promise”, T. L. Nichols, Invited talk tothe Department of Nuclear Engineering and Radiological Sciences, The University of Michigan,2 February 2001.35. “Use of Positron Emission Tomography for Determination of Cellular-Level Kinetics”,T.L. Nichols, L.F. Miller, M. Khan, G.W. Kabalka, A. Rahim, G.T. Smith, A.I. Apostoaei, andC.A.Large, 13th Symposium on Microdosimetry, May 27 - June 1, 2001 and 5th MicrobeamProbes of Cellular Radiation Response, May 26 - 27, 2001, Stresa, Italy (presented during bothmeetings).36. “The Role of PET Imaging in Boron Neutron Capture Therapy”, T. L. Nichols and G. W.Kabalka, Invited talk to The University of Uppsala, Uppsala Sweden, 11 September 2001.37. “The Role of PET Imaging in Boron Neutron Capture Therapy”, T. L. Nichols and G. W.Kabalka, Invited talk to The University of Helsinki, Helsinki, Finnland, 14 September 2001.38. “The Dependence of the Microscopic Dose in Boron Neutron Capture on CellGeometry”, 10 th International Society for Neutron Capture Therapy, Essen, Germany, 2002.39. “New Insights in the Micro-Dosimetry of Boron Neutron Capture Therapy Using aMonte-Carlo Technique”, American Nuclear Society, San Diego, 2003.40. T. L. Nichols, L. F. Miller, G. W. Kabalka, “Microdosimetric study for interpretation ofoutcomes from Boron Neutron Capture Therapy clinical trials”, Tenth Symposium on NeutronDosimetry, Progress in dosimetry of neutrons and light nuclei, Uppsala, Sweden, 2006.41. R. A. Lillie, D. E. Peplow, M. L. Williams, B. L. Kirk, M. P. Langer † , T. L. Nichols †† ,andY. Y. Azmy, “Photon Beam Transport in a Voxelized Human Phantom Model: DiscreteOrdinates vs Monte Carlo, The American Nuclear Society’s 14 th Biennial Topical Meeting of theRadiation Protection and Shielding Division, Carlsbad New Mexico, 2006.42. T. L. Nichols, G. W. Kabalka, L. F. Miller, and A. Johnson, “Implications for ClinicalTreatment from the Microdosimetry of Boron Neutron Capture Therapy”, Proceedings of the 13 thInternational Congress on Neutron Capture Therapy, Florence, Italy, 2008.12

43. T. L. Nichols, “The Flowering of Neutron Capture Therapy”, NIH forum at Oak RidgeNational Laboratory, June 2009.13

MEETINGS ATTENDED AND CONTINUING MEDICAL EDUCATION:American Physical Society, Spring meeting, Washington D.C., 1978American Physical Society, Spring meeting, Washington D.C., 1979Workshop on High Spin States, Drexel University, Philadelphia, Pennsylvania, 1980Intensive Review of Internal Medicine, Emory Medical School, Atlanta, Georgia, 1987Update in Infectious Disease for the Internist, Medical University of South Carolina,Hilton Head, South Carolina, 1988Cardiology for the Internist, Mayo Clinic, Orlando, Florida, 1989Internal Medicine Board Review, Miami University Medical School, Miami, Florida,1990Update in Internal Medicine, Harvard Medical School and Beth Israel DeaconessMedical Center, Boston, Massachusetts, 1995Update in Internal Medicine, Harvard Medical School and Massachusetts GeneralHospital, Boston, Massachusetts, 1996International Society for Neutron Capture Therapy, Zurich, Switzerland, 1996Division of Nuclear Physics, American Physical Society, Fall Meeting, Boston,Massachusetts, 1996Update in Internal Medicine, Harvard Medical School and Beth Israel DeaconessMedical Center, Boston, Massachusetts, 1997American Physical Society, Spring meeting, Atlanta, Georgia, 1998International Society for Neutron Capture Therapy, LaJolla, California, 1998Update in Internal Medicine, Harvard Medical School and Beth Israel DeaconessMedical Center, Boston, Massachusetts, 1998Update in Internal Medicine, Harvard Medical School and Beth Israel DeaconessMedical Center, Boston, Massachusetts, 1999International Society for Neutron Capture Therapy, Osaka, Japan, 2000Update in Internal Medicine, Harvard Medical School and Beth Israel DeaconessMedical Center, Boston, Massachusetts, 200013th Symposium on Microdosimetry, Stresa, Italy, 20015th Microbeam Probes of Cellular Radiation Response, Stresa, Italy, 2001Workshop on Monte-Carlo Techniques in Radiation Therapy, National Institutes ofHealth, Gatlinburg, Tennessee, 2001Update in Internal Medicine, Harvard Medical School and Beth Israel DeaconessMedical Center, Boston, Massachusetts, 2001International Society for Neutron Capture Therapy, Essen, Germany, 2002Update in Internal Medicine, Harvard Medical School and Beth Israel DeaconessMedical Center, Boston, Massachusetts, 2002American Nuclear Society, San Diego, 2003American College of Physicians, New Orleans, 2004Society of Hospital Medicine, Chicago, 200514

RESEARCH GRANTS AWARDED:DOE, #DE-FG02-96ER62189, Molecular Medicine: Synthesis and in Vivo Detection ofAgents for use in Boron Neutron Capture Therapy, Co-PI, 5/1/00 – 4/30/03.DOE LDRD Program, Novel Treatment for Biological Warfare Pathogens, Co-PI,1/1/2003 – 1/1/2004NIH, #4000053123 sub-contract with ORNL, Deterministic Radiation Transport forRadiation Treatment Planning, PI, 8/30/2005-8/29/200815