Decompressive Craniectomy in Diffuse Traumatic Brain Injury - ICU

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StatisticsProportion of favorable outcomes (defined as a score of 5 to 8 on theExtended Glasgow Outcome Scale) from 30% among patients receivingstandard care to 50% among patients undergoing craniectomy, with a twosidedtype I error of 0.05 and a power of 80% with a sample size of 210patients.At the interim analysis (with the study-group assignments concealed), itwas determined that if the score on the 8-grade Extended Glasgow OutcomeScore were analyzed by ordinal logistic regression, 150 patientswould be required to detect a between-group difference of 1.5 in the medianscore with a power of 80% and a two-sided type I error of 0.05.8
StatisticsOrdinal logistic regression for univariate between-group comparisons ofscores on the Extended Glasgow Outcome ScaleLogistic regression for comparisons of unfavorable outcomes.Followed by adjusted comparisons with inclusion in the regression modelsof the prespecified covariates:age,the last Glasgow Coma Scale score before intubationGlasgow Coma Scale motor score after resuscitationThe Marshall class.A post hoc adjusted comparison included one variable (pupil reactivity) thatdiffered significantly between groups at baseline.9
Page 1 and 2: Original ArticleDecompressive Crani
Page 3: Design Inclusion Between 15-59 year
Page 6 and 7: Second line TreatmentFor refractory
Page 10 and 11: Intracranial Pressure before and af
Page 12 and 13: Baseline Characteristics of the Pat
Page 14 and 15: Medical and Surgical Complications.
Page 16 and 17: Conclusions In adults with severe d
Page 18: LimitationsOnly assesors were blind

Decompressive Craniectomy in Diffuse Traumatic Brain Injury - ICU

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