Decompressive Craniectomy in Diffuse Traumatic Brain Injury - ICU

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Second line TreatmentFor refractory ICP > 20 after randomizationFor Both Groups: Mild Hypothermia (T° 35 C) Optimized use of barbiturates6
Outcome Measuresevaluated by telephone by three trained blinded assessorsoriginal primary outcome was the proportion of patients with an unfavorableoutcome: a composite of death, a vegetative state, or severe disability (a score of 1 to 4 on theExtended Glasgow Outcome Scale), as assessed with the use of a structured, validatedtelephone questionnaire at 6 months after injury.After the interim analysis in January 2007, the primary outcome was revised tobe the functional outcome at 6 months after injury on the basis of proportional oddsanalysis of the Extended Glasgow Outcome Scale.Secondary outcomes:intracranial pressure measured hourlythe intracranial hypertension index (defined as the number of end-hourly measures ofintracranial pressure of more than 20 mm Hg divided by the total number ofmeasurements, multiplied by 100)the proportion of survivors with a score of 2 to 4 on the Extended Glasgow Outcome Scale(defined as severe disability and requiring assistance in daily living activities)the numbers of days in the ICU and in the hospital7
Page 1 and 2: Original ArticleDecompressive Crani
Page 3: Design Inclusion Between 15-59 year
Page 8 and 9: StatisticsProportion of favorable o
Page 10 and 11: Intracranial Pressure before and af
Page 12 and 13: Baseline Characteristics of the Pat
Page 14 and 15: Medical and Surgical Complications.
Page 16 and 17: Conclusions In adults with severe d
Page 18: LimitationsOnly assesors were blind

Decompressive Craniectomy in Diffuse Traumatic Brain Injury - ICU

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