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Proceeding of the 4 rd International Symposium“NEW RESEARCH IN BIOTECHNOLOGY” USAMV Bucharest, Romania, 2011Figure 6. Normalized Fluorescence emission spectra of the pigment in the luminol (LH 2 ) (2.5 × 10 -5 M) – hydrogen peroxide (30 mM), in Tris-HCl buffer (pH 8.10).Figure 3 Cicatrisation effect of biomaterial obtained from Monascus1544. CONCLUSIONOptical spectroscopic characteristics of the pigment reveal the following: by UV-VISinvestigation, in etanol media, two absorption bands at 374 and 508 nm was obtainedrespectively. Using different excitation wavelengths, in fluorescence emission three wellstructured emission bands were evidenced at 430, 455 and 525 nm respectively in aqueousas well as in ethanol solution.Antioxidant activity of the pigment was found around 90% is attributed a good stability tothe oxidative processes. The results reveal the positive effect recordered by Monascus
Proceeding of the 4 rd International Symposium“NEW RESEARCH IN BIOTECHNOLOGY” USAMV Bucharest, Romania, 2011sp.metabolites. In this case, this product increased the rate of cicatrisation process with 70%in comparison with placebo tests in the case in which these bioproducts was administered inthe 4 day of post skin excision. The improvement of scars retraction can be due to presenceof some compound based on glucosamine derivate present in the Monascus metabolites.Further study are needed to determine the therapeutic effect of other active component fromred yeast rice, including sterols, isoflavones and tannins.ACKNOWLEDGEMENTS. The work was financially supported by the projectPOSDRU/89/1.5/S/52432 from 1.04.2010 - Institutional organization of a postdoctoralschool of national interest "Applied biotechnology with impact in the Romanian economy";the project was cofunded by the EU Social Fund in the framework of the SectorialOperational Programme 2007-2013 for Human Resources DevelopmentREFERENCES1.Akihisa, T., Tokuda, H., (2005), Azaphilones furanoisophthalides, and aminoacids from theextracts of Monascus pilosus-fermented rice (red mould rice) and ther chemopreventive effects.J.Agric. Food Chem., 53, (3) 562-565.2.Hossain, C.F., Okuyama, E., Yamazaki M., (1996). A new series of coumarin derivativeshaving monoamine oxidase inhibitory activity from Monascus anka. Chem. Pharm. Bull., 44 (8),1535-1539.3. Taira, J., Miyagi, C., Aniya, Y., (2002). Dimerumic acid as an antioxidant of the mold,Monascus anka: the inhibition mechanism against lipid peroxidation and hemeprotein-mediatedoxidation. Biochem. Pharmacol, 63 (5), 1019-1026.4.Ming, J.C. , Ming D. W., Ping S. Y., (2010), Secondary metabolites isolated from the fungusmonascus kaoliang-fermented rice. J. Chil. Chem. Soc, 55(1), 107-1105.Xijun, L., Changlu, W. (2007), Identified of new red pigment produced by Monascus ruber.Dyes and Pigments, 73, 121-125.6. Suchada, J., Prasat, K, Busaba, Y et all. (2004, )Azaphilone pigments from yellow mutant ofthe fungus Monascus kaoliang, Phytochemistry, 65, 2569-25757.Ming, D.W., Ming, J.C. (2011), Monasciotinates A-D Four new puiridine Alcaloids from theMonascus Pilosus BCRC 38093. Molecules, 16, 4719-47278. Hsu, Y.W., Hsu, L.C. (2011), New bioactive orange pigment with yellow fluorescence fromMonascus fermented Discorea. Journal of Agricultural and Food Chemistry, 59, 4511-4520.155
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