Synthesis of Some New Quinazoline Derivatives ... - AstonJournals

4 Research Article5e 4-OCH 3 4-OCH 3 65%; 253-255; Anal. Calcd. For C 26 H 24 N 2 SO 2 : C 72.89; H 5.61; N 6.54.Found: C 72.76; H 5.57; N 6.49 %5f 4-OCH 3 2,3(O-CH 2 -O)78%; 247-249; Anal. Calcd. For C 26 H 22 N 2 SO 3 : C 70.59; H 4.98; N 6.33.Found: C 70.48; H 4.89; N 6.39 %5g 4-OCH 3 4-Br 254-255; Anal. Calcd. For C 25 H 21 N 2 SO: C 62.76; H 4.39; N 5.86. Found: C62.69; H 4.30; N 5.74 %5h 4-OCH 3 3-OH 269-271; Anal. Calcd. For C 25 H 22 N 2 SO 2 : C 72.46; H 5.31; N 6.76. Found: C72.52; H 5.39; N 6.82 %5i 4-OCH 3 4-CH 3 74%; 245-247; 2919.6 (arom. C-H str.), 2596.4 (S-H), 1600 (C=N), 1586.6(C=C), 1453.6( C --- C ); 1317.6 (C-N)Anal. Calcd. For C 26 H 24 N 2 SO: C 75.73; H 5.82; N 6.79. Found: C 75.68; H5.77; N 6.69 %6a 4-Cl H 71%; 242-244; Anal. Calcd. For C 24 H 19 N 2 S: C 71.64; H 4.73; N 6.96. Found:C 71.52; H 4.79; N 6.88 %6b 4-Cl 2,4(Cl) 58%; 254-256; Anal. Calcd. For C 24 H 17 N 2 S: C 61.28; H 3.62; N 5.95. Found:C 61.23; H 3.68; N 5.89 %6c 4-Cl 4-NO 2 33%; 229-231; Anal. Calcd. For C 24 H 18 N 3 SO 2 : C 64.43; H 4.03; N 9.39.Found: C 64.47; H 4.09; N 9.25 %6d 4-Cl 3-NO 2 37%; 244-246; Anal. Calcd. For C 24 H 18 N 3 SO 2 : C 64.43; H 4.03; N 9.39.Found: C 64.39; H 4.11; N 9.29 %6e 4-Cl 4-OCH 3 10%; 235-237; Anal. Calcd. For C 25 H 21 N 2 SO: C 69.44; H 4.86; N 6.48.Found: C 69.47; H 4.78; N 6.32%6f 4-Cl 2,3(O-CH 2 -O)79%; 240-242; Anal. Calcd. For C 25 H 19 N 2 SO 2 : C 67.26; H 4.26; N 6.28.Found: C 67.19; H 4.23; N 6.24 %6g 4-Cl 4-Br 31%; 253-255; Anal. Calcd. For C 24 H 18 N 2 S: C 59.75; H 3.73; N 5.81. Found:C 59.67; H 3.65; N 5.72 %6h 4-Cl 3-OH 37%; 264-266; Anal. Calcd. For C 24 H 19 N 2 SO: C 68.89; H 4.54; N 6.69.Found: C 68.80; H 4.42; N 6.58 %6i 4-Cl 4-CH 3 74%; 255-256; 2925.9 (arom. C-H str.), 2590 (S-H), 1617.2 (C=N), 1559.8(C=C), 1494.2( C --- C ); 1289.2 (C-N)357, 229,129, 128, 127, 125, 92, 65, 26Anal. Calcd. For C 25 H 21 N 2 S: C 72.11; H 5.05; N 6.73. Found: C 72.02; H5.12; N 6.65 %7a 4-COOH H 71%; 2911.7 (arom. C-H), 2596 (S-H), 1613.8 (C=N), 1513.8 (C=C), 1431.7(C --- C ); 1394.5 (C-N)Anal. Calcd. For C 25 H 20 N 2 SO 2 : C 72.81; H 4.85; N 6.79. Found: C 72.72; H4.93; N 6.68 %7i 4-COOH 4-CH 3 46%; 2919.5 (arom. C-H), 2603.9 (S-H), 1601.2 (C=N), 1586.6 (C=C),7f 4-COOH 2,3(O-CH 2 -O)1455.3 ( C --- C ); 1317.7 (C-N)Anal. Calcd. For C 26 H 22 N 2 S: C 73.23; H 5.16; N 6.57. Found: C 73.15; H5.12; N 6.65 %71%; 230-232(d); 91 (2.01%), 65.05 (1.88%), 52.40 (1.50%), 43.90(100%)Anal. Calcd. For C 26 H 20 N 2 SO 4 : C 68.42; H 4.38; N 6.14. Found: C 68.32; H4.29; N 6.09 %8a H H 2874.1 (arom. C-H), 2588.9 (S-H), 1600 (C=N), 1557.8 (C=C), 1494.3(C --- C ); 1328.7 (C-N)Anal. Calcd. For C 24 H 20 N 2 S: C 78.26; H 5.55; N 7.61. Found: C 78.35; H5.48; N 7.72 %8e H 4-OCH 3 2871.6 (arom. C-H), 2589 (S-H), 1600.1 (C=N), 1494.6 (C=C), 1328.7 (C-N)Anal. Calcd. For C 25 H 22 N 2 S: C 75.37; H 5.53; N 7.03. Found: C 75.28; H5.43; N 7.24 %8i H 4-CH 3 2590 (S-H), 1654.1 (C=N), 1508.3 (C=C)Anal. Calcd. For C 25 H 22 N 2 S: C 78.53; H 5.76; N 7.33. Found: C 78.46; H5.82; N 7.21 %9i 2-NH 2 4-CH 3 3334 & 3412 (N-H), 2924 (arom. C-H), 2596.4 (S-H), 1577 (C=N), 1540.9(C=C), 1463.8 (C --- C ); 1316.7 (C-N)269, 176, 128, 127, 106, 92, 65, 59, 41Anal. Calcd. For C 25 H 23 N 3 S: C 75.56; H 5.79; N 10.57. Found: C 75.67; H5.70; N 10.46 %http://astonjournals.com/csj