FGF-signalling in the differentiation of mouse ES cells towards ...

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5. Paper IIFGFR(IIIc)-activation induces mesendoderm but is dispensable for definitiveendoderm formation in mouse embryonic stem cellsManuscript to be submitted.Janny Marie L. Peterslund and Palle Serup*Department of Stem Cell Biology, Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark. * Corresponding author.Author contributionsJanny Marie L. Peterslund performed the experiments, analyzed and interpreted the data, madethe figures and wrote the paper draft. Palle Serup conceived ideas, commented on the paper andwas the principal investigator and supervisor on the research. Both authors designed theresearch and discussed the results.For co-authorship declaration, see Appendix B.57
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PhD thesisCand.scient. Janny Marie
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ResuméSukkersyge er en sygdom der
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Table of contents1
Page 12 and 13: ICMinner cell massIdInhibitor of di
Page 14 and 15: cell mass regenerates probably thro
Page 16 and 17: Figure 1-1: Early embryo developmen
Page 18 and 19: Figure 1-3: Regional expression of
Page 20 and 21: The pluripotent stateThe pluripoten
Page 25 and 26: There are four membrane-bound FGFRs
Page 27: 2. AimsThe aim of this study was to
Page 30 and 31: Developmental Biology 330 (2009) 28
Page 32 and 33: 288 M. Hansson et al. / Development
Page 50 and 51: Figure S2Figure S2: A subpopulation
Page 52 and 53: Figure S4Figure S4: Expression of T
Page 54 and 55: Figure S6Figure S6: qRT-PCR analyse
Page 56 and 57: epithelium; Cdx2, expressed posteri
Page 58 and 59: Figure 4-4: A high FGF4-concentrati
Page 60 and 61: Figure 4-6: A 3-step protocol does
Page 64 and 65: FGFR(IIIc)-activation induces mesen
Page 66 and 67: IntroductionBased on knowledge obta
Page 68 and 69: For analysis of cells stained with
Page 70 and 71: they were divided into three catego
Page 72 and 73: and 9 being the most effective ones
Page 74 and 75: Most of the remaining cells are Sox
Page 76 and 77: used in this paper. Modified from (
Page 78 and 79: Gadue, P., T.L. Huber, P.J. Paddiso
Page 80 and 81: Ying, Q.L., J. Nichols, I. Chambers
Page 82 and 83: Figure 2: Activation of FGFRc-isofo
Page 84: Figure 4: FGFs activating FGFRc-iso
Page 88 and 89: Figure S2: A few areas of SOX7 + ce
Page 90 and 91: The definitive problem of endodermW
Page 92 and 93: involved in WNT-signalling and main
Page 94: 2008). Lineage tracing of these cel
Page 98 and 99: 7. ReferencesAllen, B.L. and A.C. R
Page 100 and 101: Gadue, P., T.L. Huber, P.J. Paddiso
Page 102 and 103: Madsen, O.D. and P. Serup. 2006. To
Page 104 and 105: Rodaway, A. and R. Patient. 2001. M
Page 106: Yamanaka, S. 2009. A fresh look at
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