FGF-signalling in the differentiation of mouse ES cells towards ...

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3. Paper IA late requirement for Wnt and FGF signaling during activin-induced formationof foregut endoderm from mouse embryonic stem cellsPublished in Developmental Biology, 2009, 330, p. 286 – 304.Mattias Hansson a,1 , Dorthe R- Olesen a,b,1 , Janny M.L. Peterslund a , Nina Engberg a , MortenKahn a,b , Maria Winzi a , Tino Klein a , Poul Maddox-Hyttel b and Palle Serup a, *a Department of Developmental Biology, Hagedorn Research Institute, Niels Steensens Vej 6,DK-2820 Gentofte, Denmark. b Department of Animal and Veterinary Basic Sciences, Faculty ofLife Sciences, University of Copenhagen, DK-1870 Frederiksberg C, Denmark. 1 These authorscontributed equally to this work. * Corresponding author.Author contributionsThe majority of the experiments were performed in collaboration between Mattias Hansson andDorthe R. Olesen with equal contributions. I worked on the effect of FGF-signalling upon foregutendoderm formation, and in collaboration with Nina Engberg looked at the further patterning ofactivin-induced definitive endoderm towards Pdx1-expressing pancreatic endoderm. The paperwas published in Developmental Biology, issue 330, 2009. Stated below is each individual’scontribution to the paper (numbers indicate figures).Mattias Hansson 1; 2; 3; 4A; 7; 10; 11; S1; S2; S3B,C; S4; Wrote paper draftDorthe R. Olesen 1; 2; 3; 4A,C,F; 5; 8B; S1; S2Janny M. L. Peterslund 8A; 9; 10; 12; S4Nina Engberg 4B,D,E; 12Morten KahnS3A; S5B,CMaria Winzi6; S6Tino KleinS5APoul Maddox-Hyttel SupervisorPalle SerupPrincipal investigator and supervisor; paper revisionFor co-authorship declaration, see Appendix A.21
Page 1: PhD thesisCand.scient. Janny Marie
Page 5: ResuméSukkersyge er en sygdom der
Page 9: Table of contents1
Page 12 and 13: ICMinner cell massIdInhibitor of di
Page 14 and 15: cell mass regenerates probably thro
Page 16 and 17: Figure 1-1: Early embryo developmen
Page 18 and 19: Figure 1-3: Regional expression of
Page 20 and 21: The pluripotent stateThe pluripoten
Page 25 and 26: There are four membrane-bound FGFRs
Page 27: 2. AimsThe aim of this study was to
Page 31 and 32: M. Hansson et al. / Developmental B
Page 49 and 50: Supplementary data, Paper I‘A lat
Page 51 and 52: Figure S3Figure S3: ES cell progeny
Page 53 and 54: Figure S547
Page 55 and 56: 4. Pxd1 inductionBackgroundThe work
Page 57 and 58: Figure 4-2: WNT3a and FGF4 in Step
Page 59 and 60: Figure 4-5: Pdx1 cannot be detected
Page 61: DE in medium containing activin onl
Page 64 and 65: FGFR(IIIc)-activation induces mesen
Page 66 and 67: IntroductionBased on knowledge obta
Page 68 and 69: For analysis of cells stained with
Page 70 and 71: they were divided into three catego
Page 72 and 73: and 9 being the most effective ones
Page 74 and 75: Most of the remaining cells are Sox
Page 76 and 77: used in this paper. Modified from (
Page 78 and 79:
Gadue, P., T.L. Huber, P.J. Paddiso
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Ying, Q.L., J. Nichols, I. Chambers
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Figure 2: Activation of FGFRc-isofo
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Figure 4: FGFs activating FGFRc-iso
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Figure S2: A few areas of SOX7 + ce
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The definitive problem of endodermW
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involved in WNT-signalling and main
Page 94:
2008). Lineage tracing of these cel
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7. ReferencesAllen, B.L. and A.C. R
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Gadue, P., T.L. Huber, P.J. Paddiso
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Madsen, O.D. and P. Serup. 2006. To
Page 104 and 105:
Rodaway, A. and R. Patient. 2001. M
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Yamanaka, S. 2009. A fresh look at
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