FGF-signalling in the differentiation of mouse ES cells towards ...

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AbbreviationsAP1 activator protein 1AIPanterior intestinal portalAKTakt; protein kinase BALK4 activin receptor-like kinase 4A-Panterior-posteriorAVEanterior visceral endodermBMPbone morphogenetic proteinBSAbovine serum albuminCdx2 Homeobox transcription factor Cdx2CIPcaudal intestinal portalCxcr4 Chemokine (C-X-C motif) receptor 4DAPI 4′,6-diamidino-2-phenylindoleDEdefinitive endodermDkk1 Dickkopf 1DTTdithiotreitolEembryonic dayEBembroid bodyEdU5-ethynyl-2’-deoxyuridineEpCAM epithelial cell-adhesion moleculeEpiSC epiblast stem cellEPLearly primitive ectoderm-likeERK1/2 extracellular signal-regulated kinase1/2ESembryonic stemEvx1 Even-skipped homeobox homolog 1ExEextra-embryonic ectodermFACS fluorescence-activated cell scannerFGFfibroblast growth factorFGFR fibroblast growth factor receptorFGFRb/c fibroblast growth factor(IIIb)/(IIIc)Flk1 Fetal-like kinase 1Foxa2 Forkhead transcription box 2GAPDH glyceraldehyde 3-phosphate dehydrogenaseGATA6 GATA-binding protein 6GFPgreen fluorescent proteinGp130 glycoprotein 130GscGooseciodGSK3 glycogen synthase kinase 3hES cells human embryonic stem cellsHesx1 Homeobox expressed in ES cells 1HexHematopoietically expressed homeoboxHlxb9 Homeobox transcription factor HB9HSheparin sulfate3
Page 1: PhD thesisCand.scient. Janny Marie
Page 5: ResuméSukkersyge er en sygdom der
Page 9: Table of contents1
Page 13 and 14: 1. General introductionDiabetes mel
Page 15 and 16: SOX2 and OCT4. Later, the PE and ep
Page 17 and 18: (CIP) move rostrally (arrows in Fig
Page 19 and 20: signalling. These dynamic signallin
Page 21: Figure 1-4: Key signalling pathways
Page 26 and 27: alternative splicing of exons 8 and
Page 29 and 30: 3. Paper IA late requirement for Wn
Page 31 and 32: M. Hansson et al. / Developmental B
Page 49 and 50: Supplementary data, Paper I‘A lat
Page 51 and 52: Figure S3Figure S3: ES cell progeny
Page 53 and 54: Figure S547
Page 55 and 56: 4. Pxd1 inductionBackgroundThe work
Page 57 and 58: Figure 4-2: WNT3a and FGF4 in Step
Page 59 and 60: Figure 4-5: Pdx1 cannot be detected
Page 61:
DE in medium containing activin onl
Page 64 and 65:
FGFR(IIIc)-activation induces mesen
Page 66 and 67:
IntroductionBased on knowledge obta
Page 68 and 69:
For analysis of cells stained with
Page 70 and 71:
they were divided into three catego
Page 72 and 73:
and 9 being the most effective ones
Page 74 and 75:
Most of the remaining cells are Sox
Page 76 and 77:
used in this paper. Modified from (
Page 78 and 79:
Gadue, P., T.L. Huber, P.J. Paddiso
Page 80 and 81:
Ying, Q.L., J. Nichols, I. Chambers
Page 82 and 83:
Figure 2: Activation of FGFRc-isofo
Page 84:
Figure 4: FGFs activating FGFRc-iso
Page 88 and 89:
Figure S2: A few areas of SOX7 + ce
Page 90 and 91:
The definitive problem of endodermW
Page 92 and 93:
involved in WNT-signalling and main
Page 94:
2008). Lineage tracing of these cel
Page 98 and 99:
7. ReferencesAllen, B.L. and A.C. R
Page 100 and 101:
Gadue, P., T.L. Huber, P.J. Paddiso
Page 102 and 103:
Madsen, O.D. and P. Serup. 2006. To
Page 104 and 105:
Rodaway, A. and R. Patient. 2001. M
Page 106:
Yamanaka, S. 2009. A fresh look at
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