FGF-signalling in the differentiation of mouse ES cells towards ...

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Yamanaka, S. 2009. A fresh look at iPS cells. Cell 137: 13-7.Yamanaka, Y., F. Lanner, and J. Rossant. 2010. FGF signal-dependent segregation of primitiveendoderm and epiblast in the mouse blastocyst. Development 137: 715-24.Yang, L., S. Li, H. Hatch, K. Ahrens, J.G. Cornelius, B.E. Petersen, and A.B. Peck. 2002a. In vitro transdifferentiationof adult hepatic stem cells into pancreatic endocrine hormone-producing cells.Proc Natl Acad Sci U S A 99: 8078-83.Yang, X., D. Dormann, A.E. Munsterberg, and C.J. Weijer. 2002b. Cell movement patterns duringgastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4and FGF8. Dev Cell 3: 425-37.Yasunaga, M., S. Tada, S. Torikai-Nishikawa, Y. Nakano, M. Okada, L.M. Jakt, S. Nishikawa, T. Chiba,and T. Era. 2005. Induction and monitoring of definitive and visceral endoderm differentiationof mouse ES cells. Nat Biotechnol 23: 1542-50.Ying, Q.L., J. Nichols, I. Chambers, and A. Smith. 2003a. BMP induction of Id proteins suppressesdifferentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell115: 281-92.Ying, Q.L. and A.G. Smith. 2003. Defined conditions for neural commitment and differentiation.Methods Enzymol 365: 327-41.Ying, Q.L., M. Stavridis, D. Griffiths, M. Li, and A. Smith. 2003b. Conversion of embryonic stem cellsinto neuroectodermal precursors in adherent monoculture. Nat Biotechnol 21: 183-6.Ying, Q.L., J. Wray, J. Nichols, L. Batlle-Morera, B. Doble, J. Woodgett, P. Cohen, and A. Smith. 2008.The ground state of embryonic stem cell self-renewal. Nature 453: 519-23.Zhang, X., O.A. Ibrahimi, S.K. Olsen, H. Umemori, M. Mohammadi, and D.M. Ornitz. 2006. Receptorspecificity of the fibroblast growth factor family. The complete mammalian FGF family. J BiolChem 281: 15694-700.Zhao, M., S.A. Amiel, M.R. Christie, P. Muiesan, P. Srinivasan, W. Littlejohn, M. Rela, M. Arno, N.Heaton, and G.C. Huang. 2007. Evidence for the presence of stem cell-like progenitor cells inhuman adult pancreas. J Endocrinol 195: 407-14.100
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PhD thesisCand.scient. Janny Marie
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ResuméSukkersyge er en sygdom der
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Table of contents1
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ICMinner cell massIdInhibitor of di
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cell mass regenerates probably thro
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Figure 1-1: Early embryo developmen
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Figure 1-3: Regional expression of
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The pluripotent stateThe pluripoten
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There are four membrane-bound FGFRs
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2. AimsThe aim of this study was to
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Developmental Biology 330 (2009) 28
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288 M. Hansson et al. / Development
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Figure S2Figure S2: A subpopulation
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Figure S4Figure S4: Expression of T
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Figure S6Figure S6: qRT-PCR analyse
Page 56 and 57: epithelium; Cdx2, expressed posteri
Page 58 and 59: Figure 4-4: A high FGF4-concentrati
Page 60 and 61: Figure 4-6: A 3-step protocol does
Page 63 and 64: 5. Paper IIFGFR(IIIc)-activation in
Page 65 and 66: AbstractProgress in embryonic stem
Page 67 and 68: variants in their Ig-like domain II
Page 69 and 70: Cell count and proliferation assayC
Page 71 and 72: influence on the numbers of Sox17-G
Page 73 and 74: undifferentiated cells, we found th
Page 75 and 76: FGF4, 5, FGF8b and FGFR1, are expre
Page 77 and 78: with EdU-stain (blue sample); and w
Page 79 and 80: Olsen, S.K., J.Y. Li, C. Bromleigh,
Page 81 and 82: FiguresFigure 1: Screen for FGFR-is
Page 83 and 84: Figure 3: Activation of FGFRb or FG
Page 87 and 88: Opposite, Figure 6: In the absence
Page 89 and 90: 6. General discussionEndoderm diffe
Page 91 and 92: Overall, the multitude of FGF-signa
Page 93 and 94: transplantation is the spread of an
Page 96: AcknowledgementsThe work presented
Page 99 and 100: Chambers, I., D. Colby, M. Robertso
Page 101 and 102: Hawkins, V.J. Wroblewski, D.S. Li,
Page 103 and 104: Nishikawa, S.I., S. Nishikawa, M. H
Page 105: Tanimizu, N., H. Saito, K. Mostov,
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