Book of Abstracts - Ruhr-Universität Bochum

P-31
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Synthesis, Structures, Characterization and Biological Activities of Some
Diorganotin(IV) Complexes
See Mun Lee, *a H. Mohd. Ali, a and K. M. Lo a
a University of Malaya, Faculty of Science, Department of Chemistry, 50603 Kuala Lumpur,Malaysia.
E-mail: smlee@um.edu.my
Metal complexes are widely prepared and have been successfully used in the treatment of numerous
human diseases including cancer. Organotin(IV) complexes have been widely studied for their
biological activities such as anticancer, antihistamine, antifungal and many others. Schiff base derived
from substituted salicylaldehyde has been widely used as polydentate ligands in the preparation of
metal complexes. In our present studies, a series of Schiff base ligands were prepared by reacting 3hydroxy-2-naphthoic
hydrazide with substituted 2-hydroxyacetophenone. The diorganotin complexes
were subsequently prepared by adding the ligands with diorganotin dichloride or oxide in 1:1 molar
ratio and were characterized by various spectroscopic methods including IR, NMR spectroscopies.
The X-ray structures of some of the diorganotin complexes namely
{[1-(5-Bromo-2-oxidophenyl)ethylidene]-3-hydroxy-2-naphthohydrazidato}dimethyltin(IV)
{[1-(5-Bromo-2 oxidophenyl)ethylidene]-3-hydroxy-2-naphtho-hydrazidato}dibutyltin(IV)
{[1-(5-Chloro-2-oxidophenyl)ethylidene]-3-hydroxy-2-naphtho-hydrazidato}dimethyltin(IV) and
{[1-(5-Chloro-2-oxidophenyl)ethylidene]-3-hydroxy-2-naphtho-hydrazidato}dimethyltin(IV)
have been determined using single crystal X-ray diffractometry. The in vitro cytotoxic activity of the
Schiff base ligands and diorganotin complexes has been evaluated against several cancer cell-lines
such as HT-29, SKOV-3 and MCF7.
References
1. M. Gielen, Coord. Chem. Rev. 1996, 151, 41-51.
2. A. J. Crowe, P. J. Smith, C. J. Cardin, H. E. Parge, F. E. Smith. Cancer Lett. 1984, 24 45-48.
89