Book of Abstracts - Ruhr-Universität Bochum
Book of Abstracts - Ruhr-Universität Bochum
Book of Abstracts - Ruhr-Universität Bochum
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OP-19<br />
ISBOMC `10 5.7 – 9.7. 2010 <strong>Ruhr</strong>-<strong>Universität</strong> <strong>Bochum</strong><br />
Biological Activity <strong>of</strong> Gold and Silver Bis(Phosphino)Hydrazine Complexes<br />
Frederik H. Kriel, *a and Judy Coates a<br />
a AuTEK Biomed, Mintek, Private Bag X3015, Randburg, 2125, South Africa. E-mail:<br />
erikk@mintek.co.za<br />
The anti-tumour potential <strong>of</strong> gold(I) phosphine complexes was first identified at the time when<br />
auran<strong>of</strong>in was shown to kill tumour cells in culture. This sparked the interest <strong>of</strong> Berners-Price et al. 1,2<br />
and led to the development <strong>of</strong> the bis-chelated gold(I) phosphine anti-tumour compound<br />
[Au(bis(diphenylphospino) ethane)2]Cl and later [Au(bis(di-2-pyridalphosphino)ethane)2]Cl. Clinical<br />
development <strong>of</strong> delocalised lipophilic cations has been hindered by severe toxicity, but several classes<br />
<strong>of</strong> these compounds have demonstrated a relationship between anti-tumour selectivity and lipophilichydrophilic<br />
balance. 1,2<br />
Following on the work done by Berners-Price et al.; a series <strong>of</strong> hydrazine-bridged ligands have been<br />
synthesised to modulate the lipophilic-hydrophilic balance <strong>of</strong> the resulting complexes. 3,4 These include<br />
the phenyl, p-methoxyphenyl and p-dimethylaminophenyl derivatives <strong>of</strong> the bis-phosphine. The main<br />
focus <strong>of</strong> the research is on the group 11 transition metals and corresponding gold and silver phosphine<br />
complexes. Here we describe the anti-tumour activity and NCI 60 cell line pr<strong>of</strong>ile <strong>of</strong> these compounds.<br />
Acknowledgements<br />
The authors would like to thank the University <strong>of</strong> Pretoria for use <strong>of</strong> their facilities. Pr<strong>of</strong>. Connie<br />
Medlen, Dr. Gisella Joone and Mrs. Margo Nell for guidance. Pr<strong>of</strong>. Denver Hendricks at the<br />
University <strong>of</strong> Cape Town for reviewing the work. National Research Fund for the funding for training.<br />
The NCI for the 60 cell line screen. AuTEK Biomed (Mintek and Harmony) for permission to publish<br />
the results and financial support.<br />
References<br />
1 S. J. Berners-Price, Chem. Aust., 2004, 71, 10.<br />
2 S. J. Berners-Price, P. J. Sadler, Struc. and Bond., 1988, 70, 27.<br />
3 V. S. Reddy, K. V. Katti, Inorg. Chem., 1994, 33, 2695.<br />
4 F. H. Kriel, M. Layh, H. M. Marques, J Coates, Ph.D. Thesis, University <strong>of</strong> the Witwatersrand,<br />
2007.<br />
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