Book of Abstracts - Ruhr-Universität Bochum
Book of Abstracts - Ruhr-Universität Bochum
Book of Abstracts - Ruhr-Universität Bochum
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OP-3<br />
ISBOMC `10 5.7 – 9.7. 2010 <strong>Ruhr</strong>-<strong>Universität</strong> <strong>Bochum</strong><br />
Rhenium(I) Tricarbonyl Complexes <strong>of</strong> Benzaldehyde and Substituted<br />
Salicylaldehyde Dibenzyl Semicarbazones: Synthesis and Cytotoxicity Studies<br />
Yaw-Kai Yan, *a Siti Munira bte Haidad Ali, a and Peng-Foo Peter Lee a<br />
a Nanyang Technological University, National Institute <strong>of</strong> Education, Natural Sciences & Science<br />
Education Department, 1 Nanyang Walk, Singapore 637616. E-mail: yawkai.yan@nie.edu.sg<br />
Semicarbazones and their metal complexes are attracting interest due to their potential medicinal<br />
applications. 1 In particular, metal complexes <strong>of</strong> salicylaldehyde semicarbazones were shown to have in<br />
vitro anti-cancer activity. 2 Since rhenium(I) tricarbonyl complexes <strong>of</strong> bis(diphenylphosphinomethyl)<br />
amines and 2-(dimethylamino)ethoxide also show cytotoxic activity against several murine and human<br />
cancer cell lines, 3 we embarked on a study <strong>of</strong> the cancer cell cytotoxicity <strong>of</strong> rhenium(I) tricarbonyl<br />
complexes <strong>of</strong> N,N-disubstituted salicylaldehyde semicarbazones (SSCs), [ReBr(CO)3(SSC)]. It was<br />
found that these complexes exhibit moderate to high cytotoxicities towards MOLT-4 cells. 4 In this<br />
paper, we report our recent work on the synthesis and cytotoxicity screening <strong>of</strong> benzaldehyde and<br />
substituted salicylaldehyde dibenzyl semicarbazones, and their rhenium(I) tricarbonyl complexes<br />
(Figure). The results show that complexes 2, 3 and 5 are strongly cytotoxic against MOLT-4 cells.<br />
References<br />
1. H. Beraldo, D. Gambino, Minirev. Med. Chem. 2004, 4, 31-39. (b) Z. Afrasiabi, E. Sinn, W. Lin, Y.<br />
Ma, C. Campana, S.B. Padhyé, J. Inorg. Biochem. 2005, 99, 1526-1531. (c) J. Rivadeneira, D.A.<br />
Barrio, G. Arrambide, D. Gambino, L. Bruzzone, S.B. Etcheverry, J. Inorg. Biochem. 2009, 103, 633-<br />
642.<br />
2. (a) J. Patole, S. Padhye, M.S. Moodbidri, N. Shirsat, Eur. J. Med. Chem. 2005, 40, 1052-1055. (b)<br />
P. Noblia, M. Vieites, B. Parajon-Costa, E. Baran, H. Cerecetto, P. Draper, M. Gonzalez, O. Piro, E.<br />
Castellano, A. Azqueta, A. de Cerain, A. Monge-Vega, D. Gambino, J. Inorg. Biochem. 2005, 99,<br />
443-451.<br />
3. (a) J. Zhang, J.J. Vittal, W. Henderson, J. Wheaton, I.H. Hall, T.S.A. Hor, Y.K. Yan, J. Organomet.<br />
Chem. 2002, 650, 123-132. (b) W. Wang, Y.K. Yan, T.S.A. Hor, J.J. Vittal, J.R. Wheaton, I.H. Hall,<br />
Polyhedron 2002, 21, 1991-1999.<br />
4. J. Ho, W. Y. Lee, P. F. P. Lee, Y. K. Yan, J. Inorg. Biochem., submitted.<br />
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