FRONTESPIZIO - Cooperazione Italiana allo Sviluppo

7. HIV and skin: an operational research (O.R.) in Tigray region, Ethiopia 125back as a disease of major public health importance. It is caused by two differentspecies of trypanosomes, namely Trypanosoma brucei gambiense in Westand Central Africa, and Trypanosoma brucei rhodesiense in East Africa. T. b.gambiense has a chronic and protracted course, and may last several yearswhereas T. b. rhodesiense is acute and can cause death in a matter of weeks ormonths. Both types of sleeping sickness are fatal if left untreated. Sleepingsickness is found uniquely in sub-Saharan Africa.Trypanosomes are able to evade the immune system of the host because oftheir enormous potential for antigenic variation (over 1000 variants). It isvery difficult to treat, particularly after it has crossed the blood-brain barrier.The medicines themselves are often in short supply, difficult to administer,and can be fatal. It has been estimated that between 3 and 5% of those treatedin the last stage of illness die from the treatment itself. In addition, resistanceto currently used drugs is a serious problem. There is a clear need fornew drugs, as well as better access to currently used ones.• Background of disease• Transmission• Surveillance• History• Epidemiology and description of the data• Signs and symptoms• Therapy• Primary and secondary prevention8) Viral diseases related to skin conditions• Epidemiology• Signs and symptoms• Therapy• Primary and secondary prevention9) Bacterial Diseases related to skin conditions• Epidemiology• Signs and symptoms• Therapy• Primary and secondary prevention Program 3Guidelines for maternal, child and reproductive health.1) Menstrual period2) Menopause