Vel<strong>and</strong>er, William Chemical <strong>and</strong> Biomolecular EngineeringcGMP Recombinant FIX <strong>and</strong> Oral Hemophilia B Therapy$9,587,071 NIH-NHLBI9/6/05 – 8/31/11Van Cott, Kevin Chemical <strong>and</strong> Biomolecular EngineeringWilliam Vel<strong>and</strong>er, Donald R. Voelte Jr. <strong>and</strong>Nancy A. Keegan Endowed Chair inEngineering, is principal investigator in apartnership funded by a $9.9 million grantfrom the National Institutes <strong>of</strong> Health/National Heart, Lung <strong>and</strong> Blood Institute.The goal is to develop an abundant, pure,safe <strong>and</strong> effective therapy for Hemophilia B using recombinanthuman coagulation proteins produced in the milk <strong>of</strong> transgenicpigs. The project builds on innovative bioengineering technologiespioneered by Vel<strong>and</strong>er that enable improved intravenous <strong>and</strong> noveloral delivery <strong>of</strong> hemophilic factors to patients. Hemophilia B is acongenital bleeding disorder that causes pain, crippling injuries<strong>and</strong> early death. It can be treated by Factor IX, a blood protein, butthe costs are prohibitive <strong>and</strong> most patients do not receive it.Vel<strong>and</strong>er’s project isolates Factor IX in the milk <strong>of</strong> transgenic pigs.Production <strong>and</strong> Purification <strong>of</strong> Fibrinogen Componentsfor Production Fibrin Sealant <strong>of</strong> Hemostatic Dressing$5,398,990 DoD-AMR8/1/05 – 8/30/10Van Cott, Kevin Chemical <strong>and</strong> Biomolecular EngineeringWilliam Vel<strong>and</strong>er is also leading a project, funded by theDepartment <strong>of</strong> Defense, to develop processes to producerecombinant fibrinogen <strong>and</strong> other blood proteins for b<strong>and</strong>ages <strong>and</strong>implant devices, <strong>and</strong> to conduct research <strong>and</strong> clinical trials on theireffectiveness. The fibrinogen b<strong>and</strong>age is a potentially life-savingtechnology for patients who lose large amounts <strong>of</strong> blood. Whenapplied, the b<strong>and</strong>age immediately begins clotting the wound,stemming blood loss. The technology could be used in battlefieldor other applications where patients are hemorrhaging. Fibrinogentechnology could also play a role in helping develop implantabledevices with increased biological compatibility. Fibrinogen madefrom human plasma is scarce <strong>and</strong> expensive; Vel<strong>and</strong>er hasdeveloped a process for producing it from transgenic cattle bredwith a human gene that enables them to produce fibrinogen.Whitbeck, LesSociologyOjibwe Pathways Through the High School Years$3,121,678 NIH-NIDA9/3/05 – 6/30/12Johnson, KurtSociologyLes Whitbeck, John G. Bruhn Pr<strong>of</strong>essor <strong>of</strong>Sociology, is coordinating a seven-yearproject, funded by the National Institute onDrug Abuse, to investigate risk <strong>and</strong> resiliencefor early onset substance use <strong>and</strong> abuseamong pre-teen Native children in the UpperMidwest.20AWARDS OF $3 MILLION OR MORE
Wood, CharlesBiological Sciences/Nebraska Center for VirologyNebraska Center for Virology$5,565,196 NIH-NCRR9/16/10 – 7/31/15Charles Wood, Lewis Lehr/3M UniversityPr<strong>of</strong>essor <strong>of</strong> Biological Sciences, is thedirector <strong>of</strong> the Nebraska Center for Virology.The center, funded by the National Institutes<strong>of</strong> Health, combines the expertise <strong>and</strong>facilities <strong>of</strong> Nebraska’s leading biomedicalresearch institutions: UNL, the University <strong>of</strong>Nebraska Medical Center <strong>and</strong> Creighton University. Centerresearch addresses pathogenic <strong>and</strong> therapeutic aspects <strong>of</strong> some <strong>of</strong>the most devastating viral <strong>and</strong> neuroimmune disorders facing theglobal community, including AIDS, HIV-associated cancers,Alzheimer’s disease <strong>and</strong> chronic infections caused by herpesviruses <strong>and</strong> a new class <strong>of</strong> infectious agents called prions.Kaposi’s Sarcoma & Human Herpesvirus in Africa$3,599,105 NIH-NCI7/16/10 – 4/30/15Since the onset <strong>of</strong> the AIDS epidemic, Kaposi’s sarcoma hasbecome the most frequently diagnosed pediatric cancer insub-Saharan Africa. It is associated with Human Herpesvirus 8(HHV-8) <strong>and</strong> Kaposi’s Sarcoma Herpesvirus. The project seeksto underst<strong>and</strong> how these viruses are transmitted to children bystudying children in Lusaka, Zambia. The goal is to establishthe rates <strong>of</strong> transmission <strong>and</strong> to identify virologic, immunologic<strong>and</strong> ethnographic risk factors that predispose children to HHV-8infection. It is anticipated that the information could be used todevelop intervention strategies.Yohe, JohnAgronomy <strong>and</strong> Horticulture/International Sorghum <strong>and</strong> MilletCollaborative Research Support <strong>Program</strong>International Sorghum/Millet CollaborativeResearch Support <strong>Program</strong> (INTSORMIL)$12,900,000 USAID9/30/06 – 9/29/11Heinrichs, ElvisEntomology/INTSORMILJohnsen, Carolyn Journalism <strong>and</strong> Mass CommunicationsStruthers, AmyJournalism <strong>and</strong> Mass CommunicationsJohn Yohe, associate pr<strong>of</strong>essor in theDepartment <strong>of</strong> Agronomy <strong>and</strong> Horticulture,directs the International Sorghum/Millet(INTSORMIL) Collaborative Research Support<strong>Program</strong>. INTSORMIL is a collaborativeinternational organization that supportsresearch focused on improving nutrition <strong>and</strong>increasing income in developing countries <strong>and</strong> the United States.Scientists from U.S. l<strong>and</strong> grant universities collaborate withscientists in host countries in the development <strong>of</strong> technology toimprove production <strong>and</strong> utilization <strong>of</strong> sorghum <strong>and</strong> millet <strong>and</strong>facilitate natural resource management. Their work is done inAfrica, Eurasia, Latin America <strong>and</strong> the United States.AWARDS OF $3 MILLION OR MORE21
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