Part 6: Detection and Prevention of Foot Problems in Type 2 Diabetes

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Background - Glycaemic Control and Peripheral NeuropathyThe strong correlation between better glycaemic control and a lower incidence ofdiabetic complications has been known for a long time (Pirart, 1978). There is also astrong relationship between the level of impaired glycaemic control and the severityof diabetic peripheral sensorimotor polyneuropathy (Tkac & Bril, 1998).As reviewed in Section 1, peripheral neuropathy is a major predisposing factor forulceration and amputation in people with diabetes. The question arises as to whetherachievement of near normal blood glucose levels prevents or reduces the developmentof peripheral neuropathy.The Diabetes Control and Complications Trial (DCCT) in people with Type 1diabetes clearly demonstrated that intensive treatment which improved diabetescontrol could delay the onset or slow the progression of peripheral neuropathycompared with conventional therapy (DCCT, 1993). The risk of developing peripheralneuropathy was reduced by 69% in those without neuropathy and progression wasreduced by 67% in those who already had other microvascular complications.This section addresses the question of whether a similar effect can be achieved inpeople with Type 2 diabetes with improved diabetes control.Evidence – Glycaemic Control and Peripheral NeuropathyThe development and severity of peripheral neuropathy in Type 2 diabetes isrelated to the long-term glycaemic controlIn 1998, prior to the United Kingdom Prospective Diabetes Study (UKPDS), Gaster &Hirsh (1998) reported the results of a systematic review of 20 prospectiveobservational English language studies published since 1970 which examined theassociation between hyperglycaemia and microvascular complications andneuropathy. This review pointed out the similarity of microvascular and neuropathiccomplications in both Type 1 and Type 2 diabetes when adjusted for level ofhyperglycaemia and identified a strong association between hyperglycaemia andcomplication rate, although only 2 studies included measurements for neuropathy(Gaster & Hirsh, 1998).The Wisconsin Epidemiological Study of Diabetic Retinopathy studied peoplereceiving primary care in an 11 county area of southern Wisconsin (Klein et al, 1996).This sample included a younger onset group in which almost all had Type 1 diabetes(n=1,210) and an older onset group (n=1,780) in which 824 were taking insulin and956 were not taking insulin. After 10 years, data were available for 43% of theoriginal cohort and showed an exponential relationship between the extent ofcomplications and poorer glycaemic control (Klein et al, 1996). There was a similarrelationship between young and mature onset people with diabetes for any given levelof hyperglycaemia. In the older onset group, a trend of increasing 10-year incidenceof loss of tactile sensation or temperature sensitivity associated with increasing HbA 1clevel at baseline (with HbA 1c at 5.4 to 8.5%, 8.6 to 10.0%, 10.1 to 11.5%, and 11.6 to20.8%) was observed in those taking insulin (p
those not taking insulin (p
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National Evidence Based Guidelinesf
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Research OfficersMs Linda SmithPodi
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2.2 Issues for Foot Problems in Typ
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• Aim to achieve the best possibl
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Background - Peripheral Neuropathy
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proportion of subjects with a durat
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and an OR 1.1-7.8. This study also
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Garbalosa JC, Cavanagh PR, Wu G, Ul
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Lavery LA, Armstrong DG, Wunderlich
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Payne C. Regional variations of dia
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Tovi J, Svanborg E, Nilsson BY, Eng
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Criteria used to determine the suit
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QUESTIONS KEY WORDS NO.ARTICLESIDEN
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Part 6: Detection and Prevention of Foot Problems in Type 2 Diabetes

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