Part 6: Detection and Prevention of Foot Problems in Type 2 Diabetes

Summary - Peripheral Neuropathy as a Risk Factor• Prospective studies show a strong relationship between the presence of peripheralneuropathy (assessed by a biothesiometer or Semmes-Weinstein monofilament)and subsequent ulceration• There is a similarly strong relationship between peripheral neuropathy andsubsequent amputation• Cross-sectional studies have consistently demonstrated that peripheral neuropathyis an independent risk factor for foot ulceration and amputation in people withdiabetes• The presence of peripheral neuropathy requires other permissive factors and/or aseries of events (some of which may be preventable or reversible) to culminate inan ulcer or amputation• More research is required to clarify the factors which influence the differentpathways from peripheral neuropathy to ulceration and amputation18