QUESTIONS KEY WORDS NO.ARTICLESIDENTIFIED9. Does improvedglycaemic controldecrease thedevelopment orprogression <strong>of</strong>peripheralneuropathy?Total for Question 9NIDDM/ AND neuropathy.mpAND (glycaemic control.mp ORglycemic control.mp) MNIDDM/bl,mo,nu,cl,pa,co,pc,dh,pp,di,dt,px,rh,ep,et,th AND(CBD/ OR macrovascular.mp ORret<strong>in</strong>opathy.mp OR neuropathies/OR nephropathy.mp/ OR vasculardisease/ OR coronary disease/ ORdiabetic nephropathies/ OR CVD/OR diabetic microvascular.mp/OR diabetic angiopathies/ ORneuropathy.mp. OR diabeticneuropathy/ OR stroke.mp ORPVD.mp/) LIMIT TO (controlledcl<strong>in</strong>ical trial OR cl<strong>in</strong>ical trial ORmulticentre study OR RCT ORcl<strong>in</strong>ical trial, [phase i – iv] ORmeta analysis) M1720127410NO.RELEVANTARTICLES1654517ARTICLES TOTAL FOR LEVEL I LEVEL II LEVEL LEVEL IV TOTAL NO. HIGHESTIDENTIFIED BY REVIEWIIIREVIEWED & LEVEL OFOTHERSTRATEGIESGRADED EVIDENCE16 45 1 5 6 0 12 I<strong>Diabetes</strong> mellitus/bl, co, pc, dh,dt, th, et AND (glycemiccontrol.mp OR glycaemiccontrol.mp OR diabetescontrol.mp) AND(neuropathy.mp ORneuropathies.mp OR diabeticneuropathies/) M 99-04Risk factors/ AND diabetic foot/M, CINIDDM/co,dh,pa,dt,pp,ed,ss,ep,et,th AND (glycemic control/ ORdiabetic neuropathies/ OR bloodglucose monitor<strong>in</strong>g/ OR vasculardiseases/ OR neuropathy.mp/ ORdiabetic neuropathies/ OR riskfactors/ OR ret<strong>in</strong>opathy/ OR diet/OR diabetic angiopathies/ ORnephropathy.mp/ OR CVD/ ORret<strong>in</strong>opathy.mp/ OR glycemiccontrol.mp OR macrovascular.mpOR microvascular.mp ORdiabetes control.mp) CI53264 (M)75(CI)44546 (M)21 (CI)2134
QUESTIONS KEY WORDS NO.ARTICLESIDENTIFIED9. Does improvedglycaemic controldecrease thedevelopment orprogression <strong>of</strong>peripheralneuropathy?NIDDM/bl,co,pc,dh,dt,et,th AND(neuropathy.mp ORneuropathies.mp OR diabeticneuropathies/) AND glycaemiccontrol.mp OR glycemiccontrol.mp/ OR diabeticcontrol.mp) CI 99-04(Glycosylated hemoglob<strong>in</strong>/ ORhemoglob<strong>in</strong>A1c/ OR HbA1c.mp/)AND <strong>Diabetes</strong> mellitus/ EM6450NO.RELEVANTARTICLES016ARTICLESIDENTIFIED BYOTHERSTRATEGIESTOTAL FORREVIEWLEVEL I LEVEL II LEVELIIILEVEL IV TOTAL NO.REVIEWED &GRADEDHIGHESTLEVEL OFEVIDENCE(Glycaemic control.mp ORglycaemic control.mp ORdiabetes control/) <strong>and</strong> NIDDM/AND (peripheral neuropathy/ ORdiabetic neuropathy/ ORneuropathies) EM 99-04716<strong>Diabetes</strong> mellitus/co,rh,si,epAND Risk factors/ep,co,et,di,pc,si EM50NIDDM.mp AND (glycemiccontrol.mp OR neuropathy.mp)CO174410. Does appropriatefootwear reduceulceration <strong>and</strong>amputation?Neuropathy.mp AND glycemiccontrol.mp COTotal for Question 10(Orthopedic footwear/ OR shoes/OR footwear.mp) AND sk<strong>in</strong>ulcer/ AND diabetes mellitus/ M,CI4198226 (M)15 (CI)52522 (M)1 (CI)53 64 2 4 16 0 22 I(Orthopedic footwear/ OR shoes/OR footwear.mp) AND diabeticfoot/ M, CI221 (M)162 (CI)64 (M)51 (CI)(Orthopedic footwear/ OR shoes/OR footwear.mp) ANDamputation/ M, CI90 (M)67 (CI)10 (M)15 (CI)(Shoe/ OR footwear.mp) ANDsk<strong>in</strong> ulcer/pc,co,rh,di, si,ep,th,etAND diabetes mellitus/co,rh,si,epEM537135
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National Evidence Based Guidelinesf
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Research OfficersMs Linda SmithPodi
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2.2 Issues for Foot Problems in Typ
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• Aim to achieve the best possibl
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Background - Peripheral Neuropathy
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proportion of subjects with a durat
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and an OR 1.1-7.8. This study also
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Summary - Peripheral Neuropathy as
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Section 2: Diabetes Foot ProblemsIs
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predicting risk of amputation, 2.9
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Summary - Peripheral Vascular Disea
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Section 3: Diabetes Foot ProblemsIs
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Evidence - Foot Deformity and Previ
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people with both LJM and neuropathy
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Summary - Foot Deformity and Previo
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Section 4: Diabetes Foot ProblemsIs
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Also in the Seattle study, 67 peopl
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Summary - Ulcer as a Risk Factor fo
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Section 5: Diabetes Foot ProblemsIs
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The other frequently reported metho
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side; and 82% having the same resul
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Evidence Table: Section 5Detection
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Background - Clinical Detection of
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pulse was bilaterally absent in 1.8
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Evidence Table: Section 6AuthorClin
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Background - Frequency of Foot Exam
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Summary - Frequency of Foot Examina
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Section 8: Diabetes Foot ProblemsIs
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Behaviour assessment scores, measur
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Mazzuca et al (1986) studies 532 pe
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with before the programme, after 1-
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Evidence Table: Section 8AuthorEffe
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Background - Glycaemic Control and
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In a previous Japanese randomised s
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Evidence Table: Section 9AuthorGlyc
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Background - Footwear to Reduce Ulc
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period. In addition people without
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Comparisons of in-shoe foot pressur
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The rate of plantar callus formatio
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Evidence Table: Section 10AuthorFoo
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