G6PD deficiency in South East Asia
G6PD deficiency in South East Asia
G6PD deficiency in South East Asia
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G-6-PD Viangchan (871 G A)• MIM # 305900.0026• Am<strong>in</strong>o acid 291 ValMet• Identified by Beutler <strong>in</strong> 1991: G871A, C1311C = <strong>G6PD</strong> Jammu G871A, C1311T = <strong>G6PD</strong> Viangchan• WHO class 2 (severe <strong>deficiency</strong>)• found <strong>in</strong> several ethnic groups <strong>in</strong> Hawaii (1993): Laotian, Filip<strong>in</strong>o, Ch<strong>in</strong>ese
MUTATION IN BRIEFHUMAN MUTATION Mutation <strong>in</strong> Brief #481 (2002) Onl<strong>in</strong>eGlucose-6-Phosphate Dehydrogenase (<strong>G6PD</strong>)Mutations <strong>in</strong> Thailand: <strong>G6PD</strong> Viangchan (871G>A)Is the Most Common Deficiency Variant <strong>in</strong> the ThaiPopulationI. Nuchprayoon*, S. Sanpavat, and S. NuchprayoonDepartment of Pediatrics, Faculty of Medic<strong>in</strong>e, Chulalongkorn University, Bangkok 10330, Thailand<strong>G6PD</strong>Viangchan(871)57%<strong>G6PD</strong> <strong>deficiency</strong>prevalence Thais:Male: 11.1%Female: 5.1%N= 534<strong>G6PD</strong> "Ch<strong>in</strong>ese-5" (1024)2%10Unknown<strong>G6PD</strong> Mahidol(487)6%<strong>G6PD</strong> Canton(1376)8%<strong>G6PD</strong> Union(1360)2%<strong>G6PD</strong> Kaip<strong>in</strong>g(1388)4%
J Hum Genet (2005) 50: 448–452DOI 10.1007/s10038-005-0276-2ORIGINAL ARTICLEChalisa Louicharoen • Issarang Nuchprayoon<strong>G6PD</strong> Viangchan (871G>A) is the most common <strong>G6PD</strong>deficientvariant <strong>in</strong> the Cambodian population<strong>G6PD</strong> <strong>deficiency</strong>prevalence Cambodians:Male: 26.1%Female: 3.1%N= 226Mutations<strong>in</strong> malesUnknown7%<strong>G6PD</strong> Union(1360)3%<strong>G6PD</strong> Coimbra(592)3%<strong>G6PD</strong>Viangchan(871)87%<strong>G6PD</strong> Mahidol(487) = None
J Hum Genet (2008) 53: 48-54.DOI 10.1007/s10038-007-0217-3ORIGINAL ARTICLEGlucose-6-phosphate dehydrogenase mutations <strong>in</strong> Monand Burmese of southern MyanmarIssarang Nuchprayoon • Chalisa Louicharoen •Warisa Charoenvej<strong>G6PD</strong> Viangchan(871) = None<strong>G6PD</strong> <strong>deficiency</strong>prevalence <strong>in</strong> Mon:Male: 12 %N= 162
J Hum Genet (2008) 53: 48-54.DOI 10.1007/s10038-007-0217-3ORIGINAL ARTICLEGlucose-6-phosphate dehydrogenase mutations <strong>in</strong> Monand Burmese of southern MyanmarIssarang Nuchprayoon • Chalisa Louicharoen •Warisa Charoenvej<strong>G6PD</strong> <strong>deficiency</strong>prevalence <strong>in</strong> Burmese:Male: 10 %N= 178<strong>G6PD</strong> Viangchan(871) = None
REPORTPositively Selected <strong>G6PD</strong>-MahidolMutation Reduces Plasmodium vivaxDensity <strong>in</strong> <strong>South</strong>east <strong>Asia</strong>nsChalisa Louicharoen, 1,2* Etienne Pat<strong>in</strong>, 3* Richard Paul, 1 Issarang Nuchprayoon, 4Bhee Witoonpanich, 1 Chayanon Peerapittayamongkol, 1 § Isabelle Casademont, 1 Thanyachai Sura, 5Nan M. Laird, 6 Pratap S<strong>in</strong>ghasivanon, 7 Lluis Qu<strong>in</strong>tana-Murci, 3 ∥ Anavaj Sakuntabhai1, 5 ∥<strong>G6PD</strong> <strong>deficiency</strong>prevalence <strong>in</strong> Karen:Male: 24 %N=92511 DECEMBER 2009 VOL 326 SCIENCE www.sciencemag.org
Prevalence of <strong>G6PD</strong><strong>deficiency</strong>In <strong>South</strong>east asiansMutations of <strong>G6PD</strong>In <strong>South</strong>east <strong>Asia</strong>nsBurmese11%Mons12%Karen24%Thais12%Lao-Tians7%Cambodians26%Burmese68%Mons63%Karen90%Laotians48%Thais46%Cambodians82%<strong>G6PD</strong>Mahidol;activities10-60%<strong>G6PD</strong>Viangchan:activities
Summary:<strong>G6PD</strong> variants of<strong>South</strong>east <strong>Asia</strong>ns<strong>G6PD</strong> Canton (1376)<strong>G6PD</strong> Kaip<strong>in</strong>g (1388)<strong>G6PD</strong> Gaohe (95)<strong>G6PD</strong> Viangchan (871)<strong>G6PD</strong> Mahidol (487)<strong>G6PD</strong> Union (1360)<strong>G6PD</strong> Mediterranean (563)<strong>G6PD</strong> Vanua Lava (383T>C)
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