Lecture 2 - Center for Biomedical Optics and New Laser Systems

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Oblique R(r)Light is delivered at an angle by a optical fiber (or laser beam). The light is launched a distance of one mfp’ =1/µ s ’ into the tissue at an angle θ. The center of the diffusion process is offset from the point of point of photonentry by Δx. Hence, two measurements (Δx, δ) ----> µ a , µ s ’.row0.0CCD camera with tilted sourceopticalfiberCCDcameraδ ≈ abs(1/slope)slopeΔx1000.00.0col1000.0 2000.0 3000.0 4000.0ag_labvδ =mfp' =1( )3 µ aµ a+ µ s'1µ a+ µ s'µ a= δ 2 mfp'3' 1µ s= − µ amfp'
Oblique R(r)Light is delivered at an angle by a optical fiber (or laser beam). The light is launched a distance of one mfp’ =1/µ s ’ into the tissue at an angle θ. The center of the diffusion process is offset from the point of point of photonentry by Δx. Hence, two measurements (Δx, δ) ----> µ a , µ s ’.0.0CCD camera with tilted sourceopticalfiberCCDcameraδ ≈ abs(1/slope)sloperow1000.00.0col1000.0 2000.0 3000.0 4000.0ag_labvδ =mfp' =1( )3 µ aµ a+ µ s'1µ a+ µ s'µ a= δ 2 mfp'3' 1µ s= − µ amfp'
Page 2: Consider a cup of coffee with cream
Page 8 and 9: R ≈ e −µ a Ladd a drop ofabsor
Page 10 and 11: Measurement vs properties gridColle
Page 12 and 13: lack x = µ s ’ < 10µ ablue = co
Page 16 and 17: µ a = 0.1 cm -1
Page 18 and 19: µ a = 0.1 cm -1
Page 20 and 21: µ a = 0.1 cm -1
Page 26 and 27: CameraBeam of lightM total.std exam
Page 28 and 29: mua = 0.1mua = 0
Page 30 and 31: mua = 0.5mua = 0
Page 32 and 33: R std M total M total.std RM total
Page 34 and 35: Added absorber methodDetector sense
Page 36 and 37: Added absorber methodBeam of lightD
Page 42 and 43: 10.90.8blue = const µ s', red = co
Page 44 and 45: R total + added absorber10.90.80.70
Page 46 and 47: M = M tissueM std= S T tissueG tiss
Page 52: Reflectance-mode ConfocalMicroscopy
Page 55 and 56: Coherence gate of OCT provides a 45
Page 57 and 58: ρe −µz€~1/1000 thCMOCT
Page 59 and 60: R(z)€ρ = local reflectivity [-]
Page 61 and 62: T inT out= e −a(g)µ s z f 2Gag
Page 63 and 64: R = T inρT out= ρe −µz f= µ s
Page 65: Mietheory
Page 68 and 69: Consider a rCLSM or OCT image…
Page 70 and 71: Consider a rCLSM or OCT image…R(z
Page 75 and 76:
perturbationnormal
Page 77 and 78:
Osteogenesis Mouse imperfecta skino
Page 79 and 80:
RickyWangIn vivo optical properties
Page 81 and 82:
Smooth muscles cells cause the scat
Page 83 and 84:
ρ [dimensionless]RobertMcLaughlinU
Page 85:
Tissue OpticsSteven L. Jacquesjacqu
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Lecture 2 - Center for Biomedical Optics and New Laser Systems

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