Catalysis of Organic..

Wolf, Seebald and Tacke 4911,88Figure 4.Ranking ofsimilarities of thePd catalysts withrespect to the hypotheticalidealperformance profileshown inFigure 31,9522,12,152,252,352,452,552,7DEG-Cat 3DEG-Cat 16DEG-Cat 14DEG-Cat 12DEG-Cat 10DEG-Cat 4DEG-Cat 15DEG-Cat 2DEG-Cat 13DEG-Cat 7DEG-Cat 8DEG-Cat 11DEG-Cat 5DEG-Cat 6DEG-Cat 9DEG-Cat 12,82 4 6 8 10 12 14 16Similarity to Edited (rank)The proof that this pre-selection meets indeed the most selective catalysts for thehydrogenation of the hydroxy-olefin is derived from Figure 5. Here, the yield ofsaturated alcohol obtained by conversion of the hydroxy-olefin is plotted vs. thesimilarity values derived from the Euclidean distance between performance profilesof real catalysts (Figure 2) and the ideal profile (Figure 3). The correlation betweenyield and similarity is significant. Therefore, the catalytic performance profilingappears to be a fast and unerring method for pre-selection of catalysts for hydrogenationof multi-functional substrates.94Figure 5.Correlationbetween yield inhydroxy-alkaneand similarityvalue derivedfrom profilinganalysisYield (sat. alcohol) / %9290888684821,7 1,9 2,1 2,3 2,5 2,7 2,9Similarity (Euclidian distance)