Catalysis of Organic..

468 Chiral 2-Amino-1-Phenylethanola clear solution which, after evaporation, produced 980 mg of the white amorphousamino alcohol, 1 (90% yield, e = 98+%). The NMR and IR spectra and the HPLCtraces of 1 were identical to those of an authentic sample of (S)-(+)-2-amino-1-phenylethanol obtained from Alfa AesarAcknowledgementsWe would like to acknowledge financial support for this project from SapphireTherapeutics.References1. R.K. Atkins, J. Frazier, L. Moore, and L.O. Weigel, Tetrahedron Lett., 27, 2451,1986.2. A.I. Meyers and J. Slade, J. Org. Chem., 45, 2785 (1980)3. O. Lohse and C. Spondlin, Org. Process Res. Dev., 1, 247 (1997)4. Z. Guangyou, L. Yuquing, W. Zhaohui, H. Nohira and T. Hirose, TetrahedronAsymmetry, 14, 3297 (2003).5. E.J. Cory, R.K. Bakshi and S. Shibata, J. Amer. Chem. Soc., 109, 5551 (1987).6. E.J. Corey and C. J. Helal, Angew. Chem. Int. Ed., 37, 1986 (1998).7. R. Hett, C.H. Senanayake and S.A. Wald, Tetrahedron Lett., 39, 1705 (1998).8. J. Duquette, M. Zhang, L. Zhu and R.S. Reeves, Org. Process Res. Dev., 7, 285(2003).9. T. Ohkuma, D. Ishii, H. Takeno, R. Noyori, J. Am. Chem. Soc., 122, 6510(2000).10. T. Hamada, T. Torii, K. Izawa, R. Noyori and T. Ikariya, Org. Lett., 4, 4373(2002).11. A. Lei, S. Wu, M. He and X. Zhang, J. Am. Chem. Soc., 126, 1626 (2004).12. M.S. Gibson and R. W. Bradshaw, Angew. Chem. Int. Ed., 7, 919 (1968).13. R.L. Augustine and S.K. Tanielyan, Chem. Ind. (Dekker), 89 (Catal. Org.React.), 73 (2003).