TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

Systemic14 Human15 Human16 Human17 Human18 Humanonce(IN)once(IN)once(C)once(IN)once(IN)RespCardioGastroHematoRenalDermalDermalGastroHepaticGastroRenalTABLE 2-2. Levels of Significant Exposure to Chromium - Oral (continued)Exposure/LOAELDuration/Key to a Species Frequency NOAEL Less Serious Serious Reference/figure (Strain) (Specific Route) System (mg Cr/kg/day) (mg Cr/kg/day) (mg Cr/kg/day)Form0.04 M (enhancement ofdermatitis)0.036 (dermatitis)7.5 c M (abdominal pain andvomiting)29 b M (congested lungs, pleural Clochesy 1984;effusions) lserson et al. 1983K 2Cr 2O (VI) 729 b M (hemorrhage, cardiac arrest)29 b M (hemorrhage)29 b M (inhibited coagulation)29 b M (necrosis swelling of renaltubules)Goitre et al. 1982K 2Cr 2O (VI) 7Kaaber and Veien1977K 2Cr 2O (VI) 7Kaufman et al.1970K 2Cr 2O (VI) 77.5 c M (necrosis)4.1 d M (gastrointestinal hemorrhage) Saryan and Reedy1988CrO 3(VI)4.1 d M (acute tubular necrosis)2. HEALTH EFFECTSCHROMIUM 7719 Rat(NS)once(G)Gastro130 (hemorrhage)Ssmitz 1970K 2Cr 2O (VI) 7