TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

CHROMIUM 632. HEALTH EFFECTSchromium(VI)/m 3 and a ratio of lead to zinc chromate of 9:1. Although nickel compounds were alsopresent in the plant, 98.2% higher concentrations of airborne chromium were present than wereconcentrations of airborne nickel. Smoking histories were not available for all workers (Sheffet et al.1982). A follow-up of this study followed the cohort through 1982. Of the 453 deaths, 41 were due tolung cancer, compared with 35.3 expected based on the U.S. population rates (SMR=116, not significant).When analyzed by duration of employment, none of the SMRs were significant, but there was asignificant trend for increased risk with increasing duration of employment (p=0.04). When time sinceinitial employment was considered in the analysis, a significantly increased risk of lung cancer was foundin those employed for $10 years with $30 years since initial employment (O/E=18/9.64, SMR=190,p=0.02). Of the 41 lung cancer deaths, 24 occurred in those whose jobs involved exposure to chromatedusts (i.e., with exposures of 0.5 to >2 mg/m 3 ). Results of the analysis of SMRs and trends for these 24lung cancer deaths by duration of employment and time since initial employment along with duration ofemployment were similar to those obtained with the 41 lung cancer deaths. For those employed for$10 years and with $30 years since initial employment, O/E=6/1.87 (SMR=321, p