TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

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CHROMIUM 622. HEALTH EFFECTSsignificant) for the U.S. population comparison. To address the apparent "healthy worker" effect, themortality of workers with higher exposure ($0.01 mg chromium(VI)/m 3 ) or longer duration wascompared with that of workers with less exposure (
CHROMIUM 632. HEALTH EFFECTSchromium(VI)/m 3 and a ratio of lead to zinc chromate of 9:1. Although nickel compounds were alsopresent in the plant, 98.2% higher concentrations of airborne chromium were present than wereconcentrations of airborne nickel. Smoking histories were not available for all workers (Sheffet et al.1982). A follow-up of this study followed the cohort through 1982. Of the 453 deaths, 41 were due tolung cancer, compared with 35.3 expected based on the U.S. population rates (SMR=116, not significant).When analyzed by duration of employment, none of the SMRs were significant, but there was asignificant trend for increased risk with increasing duration of employment (p=0.04). When time sinceinitial employment was considered in the analysis, a significantly increased risk of lung cancer was foundin those employed for $10 years with $30 years since initial employment (O/E=18/9.64, SMR=190,p=0.02). Of the 41 lung cancer deaths, 24 occurred in those whose jobs involved exposure to chromatedusts (i.e., with exposures of 0.5 to >2 mg/m 3 ). Results of the analysis of SMRs and trends for these 24lung cancer deaths by duration of employment and time since initial employment along with duration ofemployment were similar to those obtained with the 41 lung cancer deaths. For those employed for$10 years and with $30 years since initial employment, O/E=6/1.87 (SMR=321, p
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TOXICOLOGICAL PROFILE FORCHROMIUMU.
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CHROMIUMiiiUPDATE STATEMENTToxicolo
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CHROMIUMviiQUICK REFERENCE FOR HEAL
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CHROMIUMxiPEER REVIEWA peer review
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CHROMIUMxiv2.2.3.1 Death ..........
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CHROMIUMxviC. ACRONYMS, ABBREVIATIO
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CHROMIUM 11. PUBLIC HEALTH STATEMEN
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Page 42 and 43: 20 Rat(Wistar)Reproductive90 d7 d/w
Page 44 and 45: 33 Rat I8 mo Resp 0.1 M Glaser et a
Page 46 and 47: 43 Human44 Human45 Human46 Human47
Page 48 and 49: forFigure 2-1. Levels of Significan
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Page 56 and 57: CHROMIUM 362. HEALTH EFFECTSsulfate
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Page 70 and 71: CHROMIUM 502. HEALTH EFFECTSChromiu
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Page 92 and 93: CHROMIUM 722. HEALTH EFFECTS1.2x10
Page 94 and 95: CHROMIUM 742. HEALTH EFFECTSchromiu
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Page 98 and 99: 20 Mouse 9 d Bd Wt 53.2 F 101 .1 F
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Page 102 and 103: Neurological45 Rat 28 d(Wistar)Repr
Page 104 and 105: 59 Mouse 85 d + 36.7 F NTP 1997(BAL
Page 106 and 107: CHRONIC EXPOSURESystemic70 Human71
Page 108 and 109: Figure 2-2. Levels of Significant E
Page 110 and 111: MinimalFigure 2-2. Levels of Signif
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Page 116 and 117: CHROMIUM 962. HEALTH EFFECTSAverage
Page 118 and 119: CHROMIUM 982. HEALTH EFFECTSchanges
Page 120 and 121: CHROMIUM 1002. HEALTH EFFECTSsperma
Page 122 and 123: CHROMIUM 1022. HEALTH EFFECTSchromi
Page 124 and 125: CHROMIUM 1042. HEALTH EFFECTS2.2.2.
Page 126 and 127: CHROMIUM 1062. HEALTH EFFECTSImpair
Page 128 and 129: CHROMIUM 1082. HEALTH EFFECTSrates
Page 130 and 131: TABLE 2-3. Levels of Significant Ex
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HumanHumanHumanHumanHumanHumanHuman
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CHRONIC EXPOSURESystemicHuman 7.5 y
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CHROMIUM 1162. HEALTH EFFECTSNo stu
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CHROMIUM 1182. HEALTH EFFECTSIrrita
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CHROMIUM 1202. HEALTH EFFECTSindust
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CHROMIUM 1222. HEALTH EFFECTSGuinea
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CHROMIUM 1242. HEALTH EFFECTSmodel,
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CHROMIUM 1262. HEALTH EFFECTSblood,
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CHROMIUM 1282. HEALTH EFFECTSchromi
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CHROMIUM 1302. HEALTH EFFECTSAlthou
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CHROMIUM 1322. HEALTH EFFECTS2.3.2
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CHROMIUM 1342. HEALTH EFFECTS2.3.2.
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CHROMIUM 1362. HEALTH EFFECTSThe di
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CHROMIUM 1382. HEALTH EFFECTS(2-5 m
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CHROMIUM 1402. HEALTH EFFECTSIn rat
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CHROMIUM 1422. HEALTH EFFECTSunstab
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CHROMIUM 1442. HEALTH EFFECTSIn add
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CHROMIUM 1462. HEALTH EFFECTSsignif
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CHROMIUM 1482. HEALTH EFFECTS2.3.4.
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CHROMIUM 1502. HEALTH EFFECTSDaily
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CHROMIUM 1522. HEALTH EFFECTS51 Chr
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CHROMIUM 1562. HEALTH EFFECTSFigure
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CHROMIUM 1582. HEALTH EFFECTSTable
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CHROMIUM 1622. HEALTH EFFECTSInterr
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CHROMIUM 1642. HEALTH EFFECTSthe bl
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CHROMIUM 1662. HEALTH EFFECTSpreval
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CHROMIUM 1682. HEALTH EFFECTS2.5 RE
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CHROMIUM 1702. HEALTH EFFECTSSevera
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CHROMIUM 1722. HEALTH EFFECTSanimal
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CHROMIUM 1742. HEALTH EFFECTSOral M
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CHROMIUM 1762. HEALTH EFFECTSfibros
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CHROMIUM 1782. HEALTH EFFECTSNausea
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CHROMIUM 1802. HEALTH EFFECTSthe pr
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CHROMIUM 1822. HEALTH EFFECTSSevere
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CHROMIUM 1842. HEALTH EFFECTSdevelo
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CHROMIUM 1862. HEALTH EFFECTSthe ce
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CHROMIUM 1882. HEALTH EFFECTSimprov
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CHROMIUM 1902. HEALTH EFFECTSchroma
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CHROMIUM 1922. HEALTH EFFECTSIn ano
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Table 2-5. Genotoxicity of Chromium
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Table 2-5. Genotoxicity of Chromium
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Species (test system)Prokaryotic or
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Species (test system)S. typhimurium
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Species (test system)Mouse A18BcR c
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Species (test system)Prokaryotic or
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Species (test system)Syrian hamster
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CHROMIUM 2082. HEALTH EFFECTSet al.
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CHROMIUM 2102. HEALTH EFFECTScancer
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CHROMIUM 2122. HEALTH EFFECTS2.6 EN
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CHROMIUM 2142. HEALTH EFFECTSChromi
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CHROMIUM 2162. HEALTH EFFECTSchromi
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CHROMIUM 2182. HEALTH EFFECTSBiolog
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CHROMIUM 2222. HEALTH EFFECTSemploy
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CHROMIUM 2242. HEALTH EFFECTSunexpe
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CHROMIUM 2262. HEALTH EFFECTSMutti
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CHROMIUM 2282. HEALTH EFFECTS1986a,
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CHROMIUM 2302. HEALTH EFFECTSconcen
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CHROMIUM 2322. HEALTH EFFECTSmentio
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CHROMIUM 2362. HEALTH EFFECTSglutat
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CHROMIUM 2382. HEALTH EFFECTS1997).
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CHROMIUM 2402. HEALTH EFFECTS
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CHROMIUM 2422. HEALTH EFFECTSlimite
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CHROMIUM 2442. HEALTH EFFECTSThe re
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CHROMIUM 2462. HEALTH EFFECTS(Nette
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CHROMIUM 2482. HEALTH EFFECTSsperma
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CHROMIUM 2502. HEALTH EFFECTSThere
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CHROMIUM 2522. HEALTH EFFECTStimesp
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CHROMIUM 2542. HEALTH EFFECTSShmito
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CHROMIUM 2562. HEALTH EFFECTShas no
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CHROMIUM 2582. HEALTH EFFECTSTable
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CharacteristicSynonym(s)Table 3-1.
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CHROMIUM 2663. CHEMICAL AND PHYSICA
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CHROMIUM 2744. PRODUCTION, IMPORT/E
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CHROMIUM 2815. POTENTIAL FOR HUMAN
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Derived from HazDat 2000Figure 5-2.
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State bTable 5-2. Releases to the E
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State bTable 5-2. Releases to the E
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CHROMIUM 3156. ANALYTICAL METHODSTh
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Sample matrixTable 6-1. Analytical
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CHROMIUM 3196. ANALYTICAL METHODS6.
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Sample matrixOccupational air(weldi
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Sample matrixWaste water 1986(chrom
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CHROMIUM 3256. ANALYTICAL METHODS6.
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CHROMIUM 3277. REGULATIONS AND ADVI
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CHROMIUM 3398. REFERENCES*Aaseth J,
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CHROMIUM 3418. REFERENCES*Anderson
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CHROMIUM 3438. REFERENCES*Baranowsk
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CHROMIUM 3458. REFERENCESBlack CB,
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CHROMIUM 3478. REFERENCES*Buckell M
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CHROMIUM 3498. REFERENCES*Chen NSC,
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CHROMIUM 3518. REFERENCESCriqui M,
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CHROMIUM 3538. REFERENCESDOD. 1947.
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CHROMIUM 3558. REFERENCES*EPA. 1984
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CHROMIUM 3578. REFERENCES*EPA. 1996
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CHROMIUM 3598. REFERENCESFlint GN,
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CHROMIUM 3618. REFERENCES*Gale TF,
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CHROMIUM 3638. REFERENCESGriepink B
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CHROMIUM 3658. REFERENCES*Hayes RB,
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CHROMIUM 3678. REFERENCESHunt CD, S
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CHROMIUM 3698. REFERENCES*Jansen LH
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CHROMIUM 3718. REFERENCESKeith RL,
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CHROMIUM 3738. REFERENCES*Korallus
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CHROMIUM 3758. REFERENCES*Laborda R
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CHROMIUM 3778. REFERENCESLees PSJ,
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CHROMIUM 3798. REFERENCES*Liu KJ, J
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CHROMIUM 3818. REFERENCES*Malm O, P
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CHROMIUM 3838. REFERENCESMehra R, B
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CHROMIUM 3858. REFERENCES*Morris B,
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CHROMIUM 3878. REFERENCES*Newbold R
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CHROMIUM 3898. REFERENCES*Novey HS,
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CHROMIUM 3918. REFERENCES*OSHA 1999
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CHROMIUM 3938. REFERENCESPiela Z, K
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CHROMIUM 3958. REFERENCESRI Div Air
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CHROMIUM 3978. REFERENCES*Sata F, A
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CHROMIUM 3998. REFERENCES*Sheppard
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CHROMIUM 4018. REFERENCES*Snyder CA
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CHROMIUM 4038. REFERENCESŠtupar J,
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CHROMIUM 4058. REFERENCESTamino G,
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CHROMIUM 4078. REFERENCES*Ueno S, S
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CHROMIUM 4098. REFERENCESWahlberg J
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CHROMIUM 4118. REFERENCES*Wiegand H
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CHROMIUM 4138. REFERENCES*Zhitkovic
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CHROMIUM 4169. GLOSSARYCase Series
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CHROMIUM 4189. GLOSSARYModifying Fa
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CHROMIUM 4209. GLOSSARYeither under
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CHROMIUM A-1APPENDIX AATSDR MINIMAL
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CHROMIUM A-3APPENDIX AMINIMAL RISK
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CHROMIUM A-5APPENDIX AMINIMAL RISK
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CHROMIUM A-7APPENDIX AWas a convers
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CHROMIUM B-2APPENDIX B(2) Exposure
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1SAMPLE6 TABLE 2-1. Levels of Signi
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CHROMIUM B-6APPENDIX BChapter 2 (Se
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CHROMIUM C-1APPENDIX CACRONYMS, ABB
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CHROMIUM C-3APPENDIX CTRITWAU.S.UFy
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