TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

26 Human27 Human28 Human29 Human0.2-23.6 yravg 2.5 yr(occup) b0.1 -26 yr5.3 yr avg(occup) bResp 1.99Hemato 1.99RespRenalRenal30 Human 7.5 yr-avg Resp(range 3-16yr)Gastro31 Human 11-19 yr Gastro32 Human 1-32 yr Renal 0.61 M7 yr avg(occup) bTABLE 2-1. Levels of Significant Exposure to Chromium - Inhalation (continued)LOAELExposure/Key to a Species duration/NOAEL Less serious Serious Reference/figure (strain) frequency System (mg Cr/m3) (mg Cr/m3)(mg Cr/m3)Form0.002 (nasal mucosa atrophy,mild decreased lungfunction)0.004 M (increased urinarybeta-2-microglobulin)0.0042 (increased prevalence ofhigh N-acetyl-B-glucosamindase levels)0.004 M (epitaxis, rhinorrhea,nasal septum ulcerationand perforation)0.004 M (stomach pains andcramps, ulcers)0.005 (gastric irritation ulcer)Korallus et al.1974aCr 2O 3andCr 2(SO 4) 3(III)Lindberg andHedenstierna1983CrO 3(VI)Lindberg andVesterberg 1983CrO 3(VI)Liu et al. 1998Cr (VI)Lucas andKrarnkowski 1975CrO 3(VI)Sterechova et al.1978Cr (VI) saltsTriebig et al. 1987Chromium (0)2. HEALTH EFFECTSCHROMIUM 23