TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

20 Rat(Wistar)Reproductive90 d7 d/wk22 hr/d21 Rat 90 d0.2 M(Wistar)7 d/wk22 hr/dCHRONIC EXPOSURESystemic22 Human 2-12yr Renal 0.075 M(occup) b23 Human 7 yr avg Renal(occup) b24 Human Resp25 Human>8 yr(occup) bGastroTABLE 2-1. Levels of Significant Exposure to Chromium - Inhalation (continued)LOAELExposure/Key to a Species duration/NOAEL Less serious Serious Reference/figure (strain) frequency System (mg Cr/m3) (mg Cr/m3)(mg Cr/m3)FormResp 0.0220.025 M (increased response to Glaser et al. 1985sheep RBC, increasedNa% of lymphocytes in2Cr 2O 72H 2O (VI)bronchoalveolar lavagefluid, increased % ofmacrophages intelophase, increasedactivity of macrophages)0.05 M (increase in retinolbinding protein andtubular antigen)0.414 (nasal septumperforation)0.414 (chronic tonsilitis,chronic pharyngitis,atrophy of larynx)Glaser et al. 1985Na 2Cr 2O 72H 2O (VI)Foa et al. 1988Cr 2O 3 (Ill)Franchini andMutti 1988CrO 3(VI)Hanslian et al.1967CrO 3(VI)Huvinen et al.1996(Ill), (VI), chromite2. HEALTH EFFECTSCHROMIUM 22