TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

15 Rabbit 4-6 wk Resp 0.6 M (decreased macrophage Johansson et al.activity, impaired lung1986b(NS) 5 d/wk6 hr/dfunction)Cr(NO 3) 39H 2O III16 Rabbit 4-6 wk Resp 0.9 M(NS) 5 d/wk6 hr/dlmmunological/Lymphoreticular17 Rat 2-4 wk(Fischer- 344) 5 d/wk5 hr/d18 Rat 2-4 wk(Fischer- 344) 5 d/wk5 hr/d19 Rat 28 d(Wistar) 7 d/wk22 hr/dTABLE 2-1. Levels of Significant Exposure to Chromium - Inhalation (continued)LOAELExposure/Key to a Species duration/NOAEL Less serious Serious Reference/figure (strain) frequency System (mg Cr/m3) (mg Cr/m3)(mg Cr/m3)Form0.36 (increased neutrophils,monocytes, anddecreased macrophagesin BAL fluid; decreasedcytokine levels)0.36 (decreased tumornecrosis factor -alphalevels and production ofsuperoxide anion andhydrogen peroxide andincreased nitric oxideproduction)0.025 M (increased response tosheep red blood cells,increased percentage oflymphocytes inbronchoalveolar lavagefluid)Johansson et al.1986bNa 2CrO 4 (VI)Cohen et al. 1998Na 2CrO 4 (VI)Cohen et al. 1998BaCrO 4 (VI)Glaser et al. 1985Na 2Cr 2O 72H 2O (VI)2. HEALTH EFFECTSCHROMIUM 21