TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

Species (test system)Subcellular targets:Escherichia coli DNANuclei of mouse L1210leukemia cellsDouble-standed M13mp2bacteriophage DNAtransferred to E. coliPuc 19 plasmid DNAPapilloma virusPSV2neo-based plasmidDNAProkaryotic organisms:Bacillus subtilisE. coli PQ37, PQ35E. coli AB1157, GC2375,UA4202, PQ30E. coli Wp2, Hs30R,B/rWP2End pointTable 2-6. Genotoxicity of Chromium(VI) In VitroDNA-protein crosslinksDNA fragmentationForward mutationsGene mutationGene mutationDNA polymerase arrestRecombinationsInduction of SOSresponseInduction of SOSresponseReverse mutationsWithactivationNo dataNo dataNo dataNo dataNo data+No data–No dataNo dataResultsWithoutactivation Reference Compound––+++–++++Fornance et al. 1981Fornance et al. 1981Snow and Xu 1989Kortenkamp et al. 1996bKowalski et al. 1996Bridgewater et al.1994b, 1998Kanematsu et al. 1980;Nakamuro et al. 1975Olivier and Marzin 1987Llagostera et al. 1986Kanematsu et al. 1980;Nakamuro et al. 1978;Nestmann et al. 1979;Venitt and Levy 1974Potassium chromatePotassium chromatePotassium chromatePotassium chromatePotassium chromateSodium dichromatePotassium chromate,potassium dichromatePotassium chromate,potassium dichromateChromium chromate,potassium dichromate,chromium trioxidePotassium dichromate,potassium chromate, sodiumchromateCHROMIUM 1972. HEALTH EFFECTS