TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

Table 2-5. Genotoxicity of Chromium In Vivo (continued)Species (test system) End point Results Reference Valence CompoundMouse erythrocytes(intraperitoneal exposure)Mouse erythrocytes(intraperitoneal exposure)Mouse erythrocytes(intraperitoneal exposure)Mouse bone marrow cells (oralexposure)Mouse bone marrow cells(gavage)Mouse bone marrow(intraperitoneal exposed)Mouse hepatocytes(intraperitoneal exposed)Mouse bone marrow(intraperitoneal exposed)Mouse (intraperitoneal exposure)Micronuclei + Itoh and Shimada 1997; Wild 1978 (VI) Potassium chromateMicronuclei – Itoh and Shimada 1996 (III) Chromium chlorideMicronuclei + Itoh and Shimada 1996 (VI) Potassium chromateMicronuclei – Mirsalis et al. 1996 (VI) Potassium chromateChromosomalaberrations+ Sarkar et al. 1993 (VI) Chromium trioxideCell mutation + Itoh and Shimada 1998 (VI) Potassium dichromateCell mutation + Itoh and Shimada 1997, 1998 (VI) Potassium dichromateMicronuclei + Chorvatovi…ová et al. 1993;Wroûska-Nofer et al. 1999Dominantlethality(VI)Potassium dichromate+ Paschin et al. 1982 (VI) Potassium dichromate– = negative results; + = positive results; (0) = 0 valence; (III) = trivalent; (VI) = hexavalent; DNA = deoxyribonucleic acid;CHROMIUM 1962. HEALTH EFFECTS