TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

Table 2-5. Genotoxicity of Chromium In VivoSpecies (test system) End point Results Reference Valence CompoundDrosophila melanogaster Gene mutation + Gava et al. 1989b; Rasmuson1985; Rodriquez-Arnaiz andMartinez 1986; Zimmering et al.1985(VI)Potassium dichromate,sodium dichromate,chromium trioxide,calcium chromateD. melanogaster Gene mutation + Olvera et al. 1993 (VI) Chromium trioxideHuman lymphocytesHuman lymphocytesHuman lymphocytesHuman lymphocytesHuman lymphocytesHuman lymphocytesHuman lymphocytesChromosomalaberrationsChromosomalaberrationsChromosomalaberrationsSister chromatidexchangesDNA strandbreaks,hydroxylation ofdeoxyquanosineSister chromatidexchangesSister chromatidexchanges, DNAstrand breaks+ Koshi et al. 1984; Sarto et al. 1982 (VI) Stainless steel,welding fumes,chromium trioxide– Hamamy et al. 1987 (III) Chrome alum(primarily chromiumsulfate)– Husgafvel-Pursiainen et al. 1982 (VI) Stainless steel,welding fumes+ Koshi et al. 1984; Lai et al. 1998;Sarto et al. 1982; Stella et al. 1982(VI)Chromium plating,stainless steel, weldingfumes, chromiumtrioxide– Gao et al. 1994 (VI) Production ofbichromate– Nagaya et al. 1991 (VI) Chromium plating+ Werfel et al. 1998 (VI) Welding fumesCHROMIUM 1942. HEALTH EFFECTS