TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

CHROMIUM 1592. HEALTH EFFECTSTable 2-4. Parameters of the O’Flaherty PBPK Model (continued)Value aDefinitionReduction0.7 First-order rate constant for reduction of Chromium(VI) to Chromium(III) in thered cell (day -1 )0.5 First-order rate constant for reduction of Cr(VI) to Cr(III) in all other tissues andin lung contents (day -1 )10.0 First-order rate constant for reduction of Cr(VI) to Cr(III) in gastrointestinal tractcontents (day -1 )Lag time forexcretion of urine0.7 Fraction of urinary chromium not excreted immediately; that is, temporarily heldin pool0.05 First-order rate constant for excretion from the retained urine pool (day -1 )0.10 Fraction of chromium in retained urine that is associated with the kidneya First value listed represents Cr(III), second value represents Cr(VI)