TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

CHROMIUM 1582. HEALTH EFFECTSTable 2-4. Parameters of the O’Flaherty PBPK ModelValue aDefinitionAbsorption0.01, 0.4 First-order rate constant for absorption from the gastrointestinal tract (day -1 )0.2, 2.0 First-order rate constant for absorption from the bioavailable lung pool (pool A)(day -1 )0.8 First-order rate constant for mucociliary clearance from pool A to thegastrointestinal tract (day -1 )0.025 First-order rate constant for mucociliary clearance from nonbioavailable lung(pool B) to the gastrointestinal tract (day -1 )1.2 First-order rate constant for transfer from pool A to pool B (day -1 )Distribution5.0, 15.0 Relative clearance of chromium into mineralizing bone (liters of blood plasmacleared per liter of new bone formed)0.0003, 1.5 Clearance from plasma to red cell (liters/day)0.007, 1.5 Clearance from plasma to kidney (liters/day)0.0001, 1.5 Clearance from plasma to liver (liters/day)0.0001, 1.5 Clearance from plasma to other well-perfused tissues (liters/day)0.0001, 0.1 Clearance from plasma to poorly-perfused tissues (liters/day)0.0001, 0.1 Clearance from plasma to bone (liters/day)0.0003, 10.0 Clearance from red cell to plasma (liters/day)0.001, 10.0 Clearance from kidney to plasma (liters/day)0.0003, 10.0 Clearance from liver to plasma (liters/day)0.001, 10.0 Clearance from other well-perfused tissues to plasma (liters/day)0.003, 10.0 Clearance from poorly perfused tissues to plasma (liters/day)0.003, 10.0 Clearance from bone to plasma (liters/day)Excretion1.5 First-order rate constant for loss of chromium from intestinal tract contents to thefeces (day -1 )0.065, 0.065 Excretion clearance from the plasma (urinary clearance) (liters/kg/day)0.0, 0.0 Fraction of body burden secreted in the bile0.0, 0.0 Fraction of body burden excreted via the gastrointestinal tract