TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

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CHROMIUM 1562. HEALTH EFFECTSFigure 2-3. Conceptual Representation of a Physiologically Based Pharmacokinetic(PBPK) Model for a Hypothetical Chemical SubstanceInhaled chemicalExhaled chemicalLungsIngestionLiverVENOUSBLOODV maxFatSlowlyperfusedtissuesRichlyperfusedtissuesKidneyK mGITractFecesARTERIALBLOODUrineSkinChemicals in aircontacting skinSource: adapted from Krishnan et al. 1994Note: This is a conceptual representation of a physiologically based pharmacokinetic(PBPK) model for a hypothetical chemical substance. The chemical substance isshown to be absorbed via the skin, by inhalation, or by ingestion, metabolized in theliver, and excreted in the urine or by exhalation.
CHROMIUM 1572. HEALTH EFFECTS2.3.5.3 Discussion of Models.The O’Flaherty Model.Risk assessment. The model accounts for most of the major features of chromium(VI) andchromium(III) absorption and kinetics in the rat, and reduction from the chromium(VI) to thechromium(III) valence state, but the bioavailability/absorbability of chromium from environmentalsources is mostly unknown, except for bioavailability/absorbability of a few chemically defined salts.Furthermore, the mechanisms by which chromium reserves from bone tissue are released into plasma aswell as age, physiological conditions and species variations are important considerations in the refinementof any PBPK model for risk assessment purposes.Description of the model. The original model (O’Flaherty 1993a) was based on a PBPK model forlead and contained 10 compartments, alveolar space, well-perfused tissues, poorly-perfused tissues,kidney, liver, intestine, blood, and intestinal tract contents. The blood compartment was divided intoplasma and red blood cells. Reduction of chromium(VI) to chromium(III) was considered to occur inevery compartment except bone. The refined model (O’Flaherty 1996) replaced the alveolar spacecompartment with a two pool lung compartment, Pool A representing bioavailable chromium for enteringeither blood or the gastrointestinal tract, and Pool B containing non-bioavailable chromium that onlymoves into the gastrointestinal tract. The intestinal tract compartment was modified so that absorbedchromium entered the liver. A urinary retention compartment was added to better fit the data. Theparameters of the model are given in Table 2-4 and the structure of the model is shown in Figure 2-4.The model was developed from several data sets in which rats were dosed with chromium(VI) orchromium(III) intravenously, orally, or by intratracheal instillation, because depending on route ofadministration, different distribution and excretion patterns occur. In cases where parameters were notavailable (absorption rates, tissue affinity, biotransformation), estimates were obtained by fitting. Thiswas done by duplicating the initial conditions of published experiments in the model, varying theunknown parameters and comparing the results of the simulation to the reported results. Tissue affinityconstants were estimated using reported chromium levels in tissues at various times after exposure.Metabolic rate constants and absorption rate constants were estimated using data for excretion ofchromium in urine and feces. The model includes exchanges of chromium between plasma and bone, and
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TOXICOLOGICAL PROFILE FORCHROMIUMU.
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CHROMIUMiiiUPDATE STATEMENTToxicolo
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CHROMIUMviiQUICK REFERENCE FOR HEAL
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CHROMIUMxiPEER REVIEWA peer review
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CHROMIUMxiv2.2.3.1 Death ..........
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CHROMIUMxviC. ACRONYMS, ABBREVIATIO
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CHROMIUM 11. PUBLIC HEALTH STATEMEN
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CHROMIUM 121. PUBLIC HEALTH STATEME
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CHROMIUM 142. HEALTH EFFECTSessenti
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CHROMIUM 162. HEALTH EFFECTSuncerta
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TABLE 2-1. Levels of Significant Ex
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11 Rat 90 d Resp 0.025 M (increased
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20 Rat(Wistar)Reproductive90 d7 d/w
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33 Rat I8 mo Resp 0.1 M Glaser et a
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43 Human44 Human45 Human46 Human47
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forFigure 2-1. Levels of Significan
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35r 35r 35r 35r 35r 35r 35r 35r 35r
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CHROMIUM 322. HEALTH EFFECTSInterme
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CHROMIUM 342. HEALTH EFFECTSexposur
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CHROMIUM 362. HEALTH EFFECTSsulfate
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CHROMIUM 382. HEALTH EFFECTScorrela
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CHROMIUM 402. HEALTH EFFECTS1953).
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CHROMIUM 422. HEALTH EFFECTSBaltimo
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CHROMIUM 442. HEALTH EFFECTSHepatic
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CHROMIUM 462. HEALTH EFFECTSdichrom
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CHROMIUM 482. HEALTH EFFECTSdamage
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CHROMIUM 502. HEALTH EFFECTSChromiu
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CHROMIUM 522. HEALTH EFFECTSAn exte
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CHROMIUM 542. HEALTH EFFECTS2.2.1.7
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CHROMIUM 562. HEALTH EFFECTS2.2.1.8
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CHROMIUM 582. HEALTH EFFECTSmajor p
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CHROMIUM 602. HEALTH EFFECTSfound a
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CHROMIUM 622. HEALTH EFFECTSsignifi
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CHROMIUM 642. HEALTH EFFECTSheavy s
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CHROMIUM 662. HEALTH EFFECTScarcino
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CHROMIUM 682. HEALTH EFFECTS(female
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CHROMIUM 702. HEALTH EFFECTSFerroch
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CHROMIUM 722. HEALTH EFFECTS1.2x10
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CHROMIUM 742. HEALTH EFFECTSchromiu
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8 Rat once 26 M (LD 50)(Fischer- 34
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20 Mouse 9 d Bd Wt 53.2 F 101 .1 F
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32 Rat(BD)33 RatSwiss albino34 RatD
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Neurological45 Rat 28 d(Wistar)Repr
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59 Mouse 85 d + 36.7 F NTP 1997(BAL
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CHRONIC EXPOSURESystemic70 Human71
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Figure 2-2. Levels of Significant E
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MinimalFigure 2-2. Levels of Signif
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CHROMIUM 922. HEALTH EFFECTSand blo
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CHROMIUM 942. HEALTH EFFECTSHematol
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CHROMIUM 962. HEALTH EFFECTSAverage
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CHROMIUM 982. HEALTH EFFECTSchanges
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CHROMIUM 1002. HEALTH EFFECTSsperma
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CHROMIUM 1022. HEALTH EFFECTSchromi
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CHROMIUM 1042. HEALTH EFFECTS2.2.2.
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Species (test system)Syrian hamster
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CHROMIUM 2082. HEALTH EFFECTSet al.
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CHROMIUM 2102. HEALTH EFFECTScancer
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CHROMIUM 2122. HEALTH EFFECTS2.6 EN
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CHROMIUM 2142. HEALTH EFFECTSChromi
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CHROMIUM 2162. HEALTH EFFECTSchromi
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CHROMIUM 2182. HEALTH EFFECTSBiolog
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CHROMIUM 2202. HEALTH EFFECTSFigure
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CHROMIUM 2222. HEALTH EFFECTSemploy
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CHROMIUM 2242. HEALTH EFFECTSunexpe
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CHROMIUM 2262. HEALTH EFFECTSMutti
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CHROMIUM 2282. HEALTH EFFECTS1986a,
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CHROMIUM 2302. HEALTH EFFECTSconcen
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CHROMIUM 2322. HEALTH EFFECTSmentio
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CHROMIUM 2342. HEALTH EFFECTS2.11.2
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CHROMIUM 2362. HEALTH EFFECTSglutat
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CHROMIUM 2382. HEALTH EFFECTS1997).
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CHROMIUM 2402. HEALTH EFFECTS
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CHROMIUM 2422. HEALTH EFFECTSlimite
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CHROMIUM 2442. HEALTH EFFECTSThe re
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CHROMIUM 2462. HEALTH EFFECTS(Nette
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CHROMIUM 2482. HEALTH EFFECTSsperma
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CHROMIUM 2502. HEALTH EFFECTSThere
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CHROMIUM 2522. HEALTH EFFECTStimesp
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CHROMIUM 2562. HEALTH EFFECTShas no
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CHROMIUM 2582. HEALTH EFFECTSTable
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CharacteristicSynonym(s)Table 3-1.
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CHROMIUM 2663. CHEMICAL AND PHYSICA
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CHROMIUM 2744. PRODUCTION, IMPORT/E
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CHROMIUM 2815. POTENTIAL FOR HUMAN
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Derived from HazDat 2000Figure 5-2.
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State bTable 5-2. Releases to the E
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State bTable 5-2. Releases to the E
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CHROMIUM 3156. ANALYTICAL METHODSTh
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Sample matrixTable 6-1. Analytical
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CHROMIUM 3196. ANALYTICAL METHODS6.
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Sample matrixOccupational air(weldi
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Sample matrixWaste water 1986(chrom
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CHROMIUM 3256. ANALYTICAL METHODS6.
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CHROMIUM 3277. REGULATIONS AND ADVI
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CHROMIUM 3398. REFERENCES*Aaseth J,
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CHROMIUM 3418. REFERENCES*Anderson
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CHROMIUM 3438. REFERENCES*Baranowsk
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CHROMIUM 3458. REFERENCESBlack CB,
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CHROMIUM 3478. REFERENCES*Buckell M
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CHROMIUM 3498. REFERENCES*Chen NSC,
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CHROMIUM 3518. REFERENCESCriqui M,
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CHROMIUM 3538. REFERENCESDOD. 1947.
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CHROMIUM 3558. REFERENCES*EPA. 1984
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CHROMIUM 3578. REFERENCES*EPA. 1996
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CHROMIUM 3598. REFERENCESFlint GN,
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CHROMIUM 3618. REFERENCES*Gale TF,
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CHROMIUM 3638. REFERENCESGriepink B
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CHROMIUM 3658. REFERENCES*Hayes RB,
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CHROMIUM 3678. REFERENCESHunt CD, S
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CHROMIUM 3698. REFERENCES*Jansen LH
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CHROMIUM 3718. REFERENCESKeith RL,
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CHROMIUM 3738. REFERENCES*Korallus
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CHROMIUM 3758. REFERENCES*Laborda R
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CHROMIUM 3778. REFERENCESLees PSJ,
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CHROMIUM 3798. REFERENCES*Liu KJ, J
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CHROMIUM 3818. REFERENCES*Malm O, P
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CHROMIUM 3838. REFERENCESMehra R, B
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CHROMIUM 3858. REFERENCES*Morris B,
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CHROMIUM 3878. REFERENCES*Newbold R
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CHROMIUM 3898. REFERENCES*Novey HS,
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CHROMIUM 3918. REFERENCES*OSHA 1999
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CHROMIUM 3938. REFERENCESPiela Z, K
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CHROMIUM 3958. REFERENCESRI Div Air
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CHROMIUM 3978. REFERENCES*Sata F, A
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CHROMIUM 3998. REFERENCES*Sheppard
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CHROMIUM 4018. REFERENCES*Snyder CA
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CHROMIUM 4038. REFERENCESŠtupar J,
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CHROMIUM 4058. REFERENCESTamino G,
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CHROMIUM 4078. REFERENCES*Ueno S, S
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CHROMIUM 4098. REFERENCESWahlberg J
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CHROMIUM 4118. REFERENCES*Wiegand H
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CHROMIUM 4138. REFERENCES*Zhitkovic
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CHROMIUM 4169. GLOSSARYCase Series
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CHROMIUM 4189. GLOSSARYModifying Fa
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CHROMIUM 4209. GLOSSARYeither under
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CHROMIUM A-1APPENDIX AATSDR MINIMAL
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CHROMIUM A-3APPENDIX AMINIMAL RISK
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CHROMIUM A-5APPENDIX AMINIMAL RISK
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CHROMIUM A-7APPENDIX AWas a convers
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CHROMIUM B-2APPENDIX B(2) Exposure
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1SAMPLE6 TABLE 2-1. Levels of Signi
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CHROMIUM B-6APPENDIX BChapter 2 (Se
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CHROMIUM C-1APPENDIX CACRONYMS, ABB
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CHROMIUM C-3APPENDIX CTRITWAU.S.UFy
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