TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

CHRONIC EXPOSURESystemicHuman 7.5 yr -avg Resp(range 3-16yr)(occup)GastroDermalRat 2 yr Dermal 15.5(Sprague- 5 d/wk mg/m3Dawley) 6 hr/da All exposures are expressed in terms of Chromium.TABLE 2-3. Levels of Significant Exposure to Chromium - Dermal (continued)Exposure/ aLOAELDuration/Species Frequency Reference/(Strain) (Specific Route) System NOAEL Less Serious Serious Form0.004 M (nasal septum ulcerationmg/m 3 and perforation)0.004 M (possible gastritis, ulcers)mg/m 30.005 M (chrome holes)mg/m 3Lucas andKrarnkowski 1975CrO 3(VI)Lee et al. 1989CrO 2(IV)(Ill) = trivalent; (VI) = hexavalent; 1 x = one time; avg = average; (C) = capsule; CrCl 3 = chromium trichloride; CrO 3 = chromium trioxide; Cr 2(SO 4) 3 = chromiumsulfate; d = day(s); F = female; Gn pig = guinea pig; hr = hour(s); K 2Cr 2O 4= potassium chromate; K 2Cr 2O 7 = potassium dichromate; kg = kilogram; LD 50= lethaldose, 50% kill; LOAEL = lowest -observed -adverse -effect level; M = male; mg = milligrams; min = minute(s); Na 2CrO 4= sodium chromate; Na 2Cr 2O 7= sodiumdichromate; Na 2Cr 2O 72H 2O = sodium dichromate dihydrate; (NH 4) 2Cr 2O 7= ammonium dichromate; NOAEL = no-observed -adverse -effect level; NS = notspecified; (Occup) = occupational; wk = week(s); yr = year(s)2. HEALTH EFFECTSCHROMIUM 114