TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

Gn pig(NS)Gn pig(NS)Rabbit(NS)Rabbit(NewZealand)Rabbit(NewZealand)Rabbit(NewZealand)Rabbit(NewZealand)3 d Dermal1 x/d3 d Dermal1 x/d5 min or 24 Ocularhr4 hr Dermal4 hr Dermal4 hr Dermal4 hr Dermallmmunological/LymphoreticularHumanHumanHumanonce48 hr48 hrTABLE 2-3. Levels of Significant Exposure to Chromium - Dermal (continued)Exposure/ aLOAELDuration/Species Frequency Reference/(Strain) (Specific Route) System NOAEL Less Serious Serious Form1 mg/kg0.1 mL Mof 1000mg/L0.35 (skin ulcers)mg/kg47 M (erythema, edema,mg/kg necrosis)42 M (erythema, edema)mg/kg55 (necrosis, erythema,mg/kg edema)47 M (necrosis, erythema,mg/kg edema)0.1 75% (positive patch test)0.001% (increased skin thicknessand blood flow)0.37 % (positive patch test)Sarnitz andEpstein 1962Cr 2(SO 4) 3(III)Sarnitz andEpstein 1962K 2Cr 2O (VI) 7Fujii et al. 1976Na 2CrO 4andNa 2Cr 2O 7(VI)Gad et al. 1986K 2Cr 2O (VI) 7Gad et al. 1986Na 2CrO (VI) 4Gad et al. 1986(NH 4) 2Cr 2O (VI) 7Gad et al. 1986Na 2Cr 2O 7(VI)Engelbrigsten1952K 2Cr 2O (VI) 7Eun and Marks1990K 2Cr 2O (VI) 7Fregert andRorsman 1964CrCl 36H 2O (III)2. HEALTH EFFECTSCHROMIUM 111