TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

59 Mouse 85 d + 36.7 F NTP 1997(BALB/c) PND 1-74K 2Cr 2O (VI) 7(F1) +PND1-21(F2)(F)60 Mouse Gd 1-19(albino) 19 d(W)61 Mouse 7 wk(BALB/c) 7 d/wk(F)62 Mouse 7 wk(BALB/c) 7 d/wk(F)Developmental63 Rat 90 d(BD) 5 d/wk(F)64 Rat 20 dSwiss albino (W)65 Rat 3 moDruckrey(W)TABLE 2-2. Levels of Significant Exposure to Chromium - Oral (continued)Exposure/LOAELDuration/Key to a Species Frequency NOAEL Less Serious Serious Reference/figure (Strain) (Specific Route) System (mg Cr/kg/day) (mg Cr/kg/day) (mg Cr/kg/day)Form180646 F (increase in fetal resorption Trivedi et al. 1989and post implantation loss) K 2Cr 2O (VI) 715.2 M (decreased Zahid et al. 1990spermatogenesis)K 2Cr 2O (VI) 79.1 M (decreased Zahid et al. 1990spermatogenesis)Cr 2(SO 4) 3(III)lvankovic andPreussrnann 1975Cr 2O 3(III)37 (increased post-implantation Kanojia et al. 1996loss and decreased numberof live fetuses)K 2Cr 2O (VI) 745 (reduced fetal caudal Kanojia et al. 1998ossification, increasedpost -implantation loss,reduced fetal weight,subhemorrhagic patches)K 2Cr 2O (VI) 72. HEALTH EFFECTSCHROMIUM 84