TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

52 Rat 9 wk(Sprague- (F)Dawley)53 Mouse 12 wk(Swiss)(W)54 Mouse 12 wk(Swiss) (W)55 Mouse 12 wk(Swiss) (W)56 Mouse 20 d(Swiss albino) (W)57 Mouse 20 dSwiss albino (W)58 Mouse 9 wk(BALB/c)(F)TABLE 2-2. Levels of Significant Exposure to Chromium - Oral (continued)Exposure/LOAELDuration/Key to a Species Frequency NOAEL Less Serious Serious Reference/figure (Strain) (Specific Route) System (mg Cr/kg/day) (mg Cr/kg/day) (mg Cr/kg/day)Form8.4 M9.8 F32.2 M48 F5 M (increased testes anddecreased preputialgland weights)NTP 1996bK 2Cr 20 7(VI)13 M (decreased number of Elbetieha andpregnant females) Al-Hamood 1997CrCl 3(Ill)5 F (decreased number ofimplantations and viablefetuses; increased ovarianand decreased uterineweights)6 M (decreased number of Elbetieha andimplantations and viable Al-Hamood 1997fetuses; increased testes K 2Cr 20 7(VI)weight)6 F (decreased number of Elbetieha andimplantations and viable Al-Hamood 1997fetuses; increased number ofmice with resorptions)K 2Cr 20 7(VI)52 F (decreased placental 98 F (preimplantation loss, Junaid et al.weight) increased resorptions) 1996aK 2Cr 20 7(VI)60 F (decreased number of 120 F (decreased number of Murthy et al. 1996follicles at differentova/mouse)K 2Cr 20 7(VI)stages of maturation)NTP 1996aK 2Cr 20 7(VI)2. HEALTH EFFECTSCHROMIUM 83