TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

Neurological45 Rat 28 d(Wistar)Reproductive46 Rat(Sprague-Dawley)47 Rat(Sprague-Dawley)48 Rat(CharlesFoster)(W)12 wk(W)12 wk(W)49 Rat 90 d(BD) 5 d/wk(F)50 Rat 20 dSwiss albino (W)TABLE 2-2. Levels of Significant Exposure to Chromium - Oral (continued)Exposure/LOAELDuration/Key to a Species Frequency NOAEL Less Serious Serious Reference/figure (Strain) (Specific Route) System (mg Cr/kg/day) (mg Cr/kg/day) (mg Cr/kg/day)Form10 M 100 M (decreased motoractivity)4042(altered sexual behavior,decreased absolutetestes, seminal vesicles,and preputial glandweights)(altered sexual behavior,decreased absolutetestes, seminal vesicles,and preputial glandweights)Diaz-Mayans et al.1986Na 2CrO 4(VI)Bataineh et al.1997CrCl (Ill) 3Bataineh et al.1997K 2Cr 2O 7(VI)90 d 20 M (decreased testicular 40 M 128% decreased testicular wt; Chowdhury and1 x/dprotein, 3 beta-hydroxydecreased testicular protein, Mitra 1995steroid dehydrogenaseDNA, RNA, seminiferous Na 2Cr 2O 7 (VI)(G)and serum testosterone)tubular diameter; decreasedLeydig cells, pachytene cells,spermatocytes, spermatids,& testosterone levels)180637lvankovic andPreussman 1975Cr 2O 3(Ill)(increased resorptions) Kanojia et al. 1996K 2Cr 2O 7(VI)2. HEALTH EFFECTSCHROMIUM 8251 Rat 3 moDruckrey (W)45(decreased fertility, increased Kanoiia et al. 1998pre- and post-implantation K 2Cr 2O 7(VI)loss)