TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

39 Mouse 12wk Bd Wt(Swiss)(W)Bd Wt40 Mouse 12 wk Bd Wt(Swiss)(W)41 Mouse 9wk Hemato(BALBIc)(F)HepaticRenalBd Wt42 Mouse 85 d + Gastro(BALB/c) PND 1-74(F1) +PND Hemato1 -21 (F2)(F)HepaticRenalBd Wt14 F7.4 M12 F1.1 M1.8 F484836.7 F36.7 F36.7 F36.7 F5 M (1 4% decrease in bodyweight gain)6 M (1 0% decrease in bodyweight gain)32.2 M (decreased mean48 F corpuscular volume)3.5 M (cytoplasmic5.6 F vacuolization ofhepatocytes)7.8 F (decreased meancorpuscular volume in43 Mouse 19 d Bd Wt 46 F 98 F (decreased maternal(albino) (W)weight gain)lmmunological/Lymphoreticular44 Rat 3-1 0 wk(Fischer- 344)(W)TABLE 2-2. Levels of Significant Exposure to Chromium - Oral (continued)Exposure/LOAELDuration/Key to a Species Frequency NOAEL Less Serious Serious Reference/figure (Strain) (Specific Route) System (mg Cr/kg/day) (mg Cr/kg/day) (mg Cr/kg/day)Form(F1)16 (increased proliferationof T- and B-lymphocytes inresponse to mitogensand antigens)Elbetieha andAl-Hamood 1997CrCI 3(III)Elbetieha andAl-Hamood 1997K 2Cr 2O 7(VI)NTP 1996aK 2Cr 2O 7(VI)NTP 1997K 2Cr 2O 7(VI)Trivedi et al. 1989K 2Cr 2O 7(VI)Snyder and Valle1991K 2Cr 2O 4(VI)2. HEALTH EFFECTSCHROMIUM 81