17/18 January 2007 Wiener Neustadt - Czelo

inhibition with minimal drug induced side effects.
The Technology
An essential component of the NovaCaps®- technology is a newly developed method for the encapsulation of
genetically modified live human cells. AUSTRIANOVA has developed this encapsulation technology especially for
the treatment of cancer.
Research and Development
AUSTRIANOVA’s encapsulation technology is an extremely versatile platform that can be applied in diverse
areas: research projects currently in progress are focused on the genetic modification of cells to convert them into
virus producing cells (ViroCaps®). It is planned to use the viruses (NovaVir®) produced from these cells as gene
transfer systems, which are able to target additional tumour types and metastases. This will enable delivery of the
therapeutic gene to the surrounding cancer cells thereby increasing the effect of the previous suicide gene
mediated cancer cell killing effect. Proof of principle for this has already been shown (Saller, et al., Encapsulated
cells producing retroviral vectors for in vivo gene transfer, J Gene Med 2002, 4, 150-160).
For more detailed information see our website:
http://www.austrianova.com/
1. Profile: Reques Measurement and/or visualisation of nanomaterials and nanostructures in
biological systems
DESCRIPTION:
We seek experts with technology to allow us to detect, visualise and/or measure nano- to micro-scaled biological
or synthetic materials under biologically stable conditions. For example, we would like to take high resolution
pictures of 50 - 150 nm sized magentic and/or flourescent particles attached to live retroviral vectors (80 - 120
nm) in order to be able to characterise the interaction. Also, we are very interested to visualise and capture the
movement of micospheres or nano-propellors attached to the rotating subunit of the F1 ATPase biomolecular
motor.
INNOVATIVE ASPECTS:
Working with state-of-the-art nanomaterials e.g. hybrid organic/inorganic NEMS
MAIN ADVANTADGES / BENEFITS:
Publication in scientific journal
Potential for furture translational research
TECHNICAL SPECIFICATIONS:
Open
CURRENT STAGE OF DEVELOPMEN
Some aspects are ready for testing and some require further development
INTELLECTUAL PROPERTY RIGHTS (IPR):
Still collecting data in order to be able to apply for patent
MARKET APPLICATIONS:
human and animal cancer gene therapy
basic and applied research with enveloped viruses
TYPE OF COLLABORATION SOUGH
We are open for all academic research collaborations, R&D projects or technology offers which will allow us to
acheive our goals.
PARTNER PROFILE:
Open
2. Profile: Reques Measurement and/or visualisation of nanomaterials and nanostructures in
biological systems
DESCRIPTION:
encapsulation of genetically modified or non-manipulated human or animal cells
INNOVATIVE ASPECTS:
world wide first GMP compliant cell encapsulation technology, allowing application of encapsulated live cells into
human patients
MAIN ADVANTADGES / BENEFITS:
cells of choice can be placed in situ where required and are fully protected from the patients immune system
due to pores in the capsules small molecules such as nutrients, activated metabolites, hormones etc. can pass
into and out of the capsules and have contact with the encapsulated cells
TECHNICAL SPECIFICATIONS: