17/18 January 2007 Wiener Neustadt - Czelo

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film polymer foils with embedded microelectrodes for both recording and stimulation. Applications for these biomedical microdevices will include stem cell research, cancer cell characterization, drug discovery, treatments for neurological disorders, and neuroprosthetic devices. As an electrical signal, the biosignal (BS) has two components: electrical potential or voltage and ionic or electronic currents (EC). The first component is sufficiently developed and does not require penetration into the substances of BS propagation. The marketable progress in transducing of the second component began when the necessary instrumentation for measurement of micro and nano dimensions had been created. The main informational flux from organs of the senses to motor nerves is transmitted through nerve fibres which consist of a myelin shield with axons as a core. Recent research results suggest that such an arrangement is similar to a transmission line. The nerve impulse in motor nerve of a frog is equal to 2 nA. Synaptic currents between first order neighbouring neurons into in vivo or brain slice preparations have an order of 50 pA. The nerve impulses passing through the fibre could be unambiguously defined by detecting the matching ionic current(s) or its superposition. Such a technique seems optimal because even precise voltage measurement could not give a current value according to the Ohm law. First of all, nerve fibre must be separated from a living organism for resistance of fibre measurement and, secondly, this resistance may vary in time. The method of transducing the vortical magnetic field from the nerve impulses by the pickip coil (PC) wrapped around the nerve fibre was advanced long ago. The electrical properties of hybrid structures consisting of arrays of nanowire FETs integrated with the individual axons and dendrites has been reported, where each nanoscale junction can be used for spatially resolved, highly sensitive detection, stimulation, and/or inhibition of neuronal signal propagation. Arrays of nanowireneuron junctions enable simultaneous measurement of the rate, amplitude, and shape of signals propagating along individual axons and dendrites. The configuration of nanowire-axon junctions in arrays, as both inputs and outputs, makes possible controlled studies of partial to complete inhibition of signal propagation by both local electrical and chemical stimuli. In addition, nanowire-axon junction arrays were integrated and tested at a level of at least 50 artificial synapses per neuron. The described transducer designed on the basis of organic and nano SuFETs are suitable for describing the wide range of EC dynamical parameters. The serial connection of the external PCs allows us to gain some integrated signal, i.e., the whole sensing or control electronic or NI, which spreads along the number of axons of the nerve fibre; the amount of ions passing through the PCs and the generalized BS passing through one or both spirals of DNA. When SuFET channel(s) of are implanted into the tissue or process we can acquire more precise data about the frequency distribution of nerve impulses (NIs), volume distribution of ionized molecules and detecting activity of individual nucleoteds. Exploitation of the parallel input to the transducer allows determination of space and time dynamics of BSs in the nerve fibre and DNA spiral(s) and also the amplification of output signal by multiplying the concentration of molecules according to a number of input BSs. After the implantation of parallel SuFET(s), the averaging or summation of this dynamic among the whole electronic circuit, nerve fibre or DNA spiral(s) is possible. The method of combining the bioelectric nature of NIs and synaptic currents between neighbouring neurons with body-temperature PC and zero resistance input of the SuFET device in order to obtain most advantageous biosensor/transducer was recently advanced. The SuFET is used as a zero-resistance ammeter which converts drain currents into gate voltages. Transducing the vortical magnetic field from the ECs (BSs) by the PC that is wrapped around the nerve fibre or DNA sequence is executed when the PC is in nano dimension. By using the said superconducting magnetometer with a room- temperature PC it is possible to create the implantable transducer. The device transduce the electronic or ionic currents of the circuits and organisms respectively into the gate voltages. These currents are passing through the CNT based channel of SuFET producing voltage on a gate; or these currents are passing through nanowired PC that connected to the SuFET’s channel and this PC receiving the vortical magnetic fields from the currents. Application variety of the novel superconducting, organic and carbon nanotubes (CNT) FETs allows us to design transducers of ECs (electronic, nerve, DNA, etc.) that transduce them into different quantities, including electric voltage, density of chemical and biomolecules. On the other hand, the said ECs can be controlled by the applied electrical signals, or bio and chemical mediums. The product work under room-temperature conditions for CNT and nanowired PC and cryogenic conditions for a SuFET device. The applications of the product are sensors of electric currents in the micro- and nanocircuits. Also is possible creating of an in vivo biosensor of the nerve signals, ionized molecules, synaptic neurocurrents, and the recombination signals in DNA for the biomedical diagnostics. The reverse functioning of the transducer allow us to control these signals by the external data. INNOVATIVE ASPECTS: The applications of the product are sensors of electric currents in the micro- and nanocircuits. Also is possible creating of an in vivo biosensor of the nerve signals, ionized molecules, synaptic neurocurrents, and the recombination signals in DNA for the biomedical diagnostics. The reverse functioning of the transducer allow us to control these signals by the external data.
The innovative aspects in relation to existing products are application of the nanoFETs in the reverse connection, passing the electrons and ions through CNT, connection PC to SuFET by the nanowires, vice versa control the biosignals by the artificial signals. MAIN ADVANTADGES / BENEFITS: The advantages of the technology in comparison to products that are already on the market are the highly sensitive transducing ability of the micro- and nanocurrents of the different nature with a minimal introduced impediments or disturbances. Also the universal transducer has the following fundamental improvements upon existing ones: a) the sign of the output voltage permits the determination of the direction of the input current passing through a single SuFET device; b) the capability to regulate the proportion of nanowires, axons, neurons or currents that are being investigated to the untouched ones- either the whole cross section of the fibre or conductor, or any part of them; c) the possibility to substitute the SuFET device or to adjust its ratings to comply with the conditions of the measurement process without repeatedly destroying tissue or conductor; d) the transducer could create conversion in both directions, respectively in passive and active modes; e) the combination of biocompatibility and tissue equivalence in both the diamond and protein-based (organic) FETs makes them naturally fit for implantation; The advantages for the partner are the leading position in R&D of nanosensors and wide range of future applications. TECHNICAL SPECIFICATIONS: The range of picked up currents varies from 0.6 nA to 10 microA, (7-0)x 10exp<strong>17</strong>/cm3 molecules, and 2-10 pH with frequencies from 20 to 2000 Hz. CURRENT STAGE OF DEVELOPMEN Development Phase INTELLECTUAL PROPERTY RIGHTS (IPR): • Patent Granted • Copyright MARKET APPLICATIONS: precise measuring instrumentation, biosensors for biomedical diagnostics, robotics. TYPE OF COLLABORATION SOUGH Licence agreement, Joint research project, Joint-venture agreement PARTNER PROFILE: Type of partner sought is R&D laboratory in a company or university. • Partner Qualification Criteria- an experienced staff in nanoelectronics and biophysics; • Tasks to be Performed by Partner- Implementation of the innovation in a laboratory and improving the design in theory • Support Provided by my Organisation- investigation of the transducing properties of the device. 3. Profile: RTD: A Magnetic Nanoscope ABSTRAC A ferroelectric (FE) or ferroelectromagnetic (FEM) polarizer with a unique fashion switching or amplifying has been designed. Control of an electromagnetic (EM) flux or optical beam (OB) has been carried out by splitting them on two parts: a pas
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• Electronics, Microelectronics
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Organisation Index Institute of Phy
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Organisation Index TECHNICAL UNIVER
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Organisation Index Faculty of Mater
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1. Profile: RTD: High sensitive wea
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New applications or new products re
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AMAG rolling GmbH Address Postfach
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Attophotonics Biosciences GmbH Addr
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austriamicrosystems Address Tobelba
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Austrian Researc Centers GmbH - ARC
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Austrian Research Centers GmbH - AR
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D. Swarovski & Co. Address Swarovsk
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FFG - EIP - Austrian EUREKA Office
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FFG Austrian Research Promotion Age
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FFG Austrian Research Promotion Age
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Happy Plating GmbH Address Leobersd
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Institute of Materials Science and
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INTELLECTUAL PROPERTY RIGHTS (IPR):
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inhibition with minimal drug induce
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Integrated Microsystems Austria Gmb
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Joanneum Research GmbH Address Stey
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Joanneum Research, Insitute of Nano
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Kunststoff-Cluster, Clusterland Obe
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M.Kaindl Flooring Address Kaindlstr
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CURRENT STAGE OF DEVELOPMEN plannin
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MAGNIFIN Magnesiaprodukte GmbH & Co
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Montanuniversität - Nanonet Styria
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Polymer Competence Center Leoben Gm
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1. Profile: Expertise: Nanoimprint
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Psisys Ing.C.Vacariu Address Suchen
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state-of-the-art characterization m
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17/18 January 2007 Wiener Neustadt - Czelo

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