Visual Psychophysics / Physiological Optics - ARVO

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ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group – Visual Psychophysics / Physiological Optics(p=0.021) and Reading index (p=0.020). IS/OS junction continuitywas associated with DVA (p=0.007), NVA (p=0.03) and SKILLscore (p=0.050). Photoreceptor layer continuity was associated withReading index (p=0.039). RPE layer continuity was associated withSKILL score (p=0.003).Conclusions: Significant associations exist between stressors ofmacular visual function such as near acuity and low luminance acuityand tomographic markers of retinal and choroidal morphology.Commercial Relationships: Ruth E. Hogg, Novartis (F), Novartis(C); George Murphy, None; Giovanni Staurenghi, OcularInstruments (P), GSK (C), Novartis (C), Alcon (C), Allergan (C),Bayer (C), Roche (C), Heidelberg Engineering (C), OD-OS (C), QLT(C), Optos (C); Chiara Rosina, None; Rufino Silva, Thea (C),Novartis (C), Bayer (C), Allergan (C), Alimera (C); Ana RitaSantos, None; Usha Chakravarthy, Bayer (C), Novartis (F),Neovista (C), Oraya (F)Program Number: 5029 Poster Board Number: A0191Presentation Time: 2:45 PM - 4:30 PMRelationship between retinal sensitivity and retinal thickness ineyes with retinal diseaseSrinivas R. Sadda, Muneeswar Nittala. Ophthalmology, Doheny EyeInstitute - USC, Los Angeles, CA.Purpose: To evaluate the point-to-point relationship between localretinal sensitivity as assessed by Optos SLO microperimetry andretinal thickness and volume as determined by optical coherencetomography (OCT).Methods: Twenty four eyes of twenty four subjects with variousretinal diseases were enrolled in this IRB-approved prospective crosssectional study. Microperimetry and spectral domain opticalcoherence tomography (SD-OCT) were obtained on the study eye ofall enrolled subjects using an Optos Spectral OCT/SLO (Optos plc,Dunfermline, UK). Microperimetry was performed with the using astandard 45 stimuli pattern spread over the central 12 degrees of themacula (foveal-centered), Goldmann III stimuli, and a 4-2-1threshold strategy. The OCT-derived retinal thickness map wasregistered to the microperimetry data by the OCT instrumentallowing point-to-point correlation between retinal sensitivity andOCT thickness. Correlation analysis was performed using a total of1080 loci.Results: The mean age of the study cohort was 69 (SD; 13) years and50 % were female. Retinal diseases in the study eyes included dryand wet age related macular degeneration, diabetic retinopathy, veinocclusions, macular telangiectasia and central serouschorioretinopathy. The mean baseline best-corrected (log MAR)visual acuity was 0.26 (Snellen ~ 20/30) and the mean (± SD) totalretinal sensitivity was 13.70 (± 2.74, range: 6.0 - 16.90) dB. The logMAR visual acuity was significantly correlated with mean retinalsensitivity (r= -0.43, p=0.05), with an expected stronger correlationfor foveal sensitivity (r= -0.74, p
ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group – Visual Psychophysics / Physiological OpticsMethods: Fourty four eyes showing untreated nAMD were examinedwith the Heidelberg Spectralis-OCT. Pateints’ reading acuity(logRAD) was assessed using a German language reading test(Radner Lesetest), visual acuity (logMAR) was assessed usingEDTRS charts.Reading- and visual performance was evaluated with respect to thefollowing OCT-findings in the subfoveal area 500x500µm:neovascular complex (NVC), fibrovascular pigment epitheliumdetachment (fPED), serous pigment epithelium detachment (sPED),subretinal fluid (SRF), intraretinal fluid (IRF) and intraretinal cysts(IRC).Results: Of 44 eyes with nAMD mean reading acuity in logRAD was0.72 ± 0.3 and mean visual acuity in logMAR was 0.59 ± 0.28showing a strong correlation of r=0.821 spearmen (P=0,000).In general, in subfoveal NVC, the mean logRAD score was 0.84 ±0.24, whereas in NVC with additional cysts the mean logRAD scorewas 1.0 ± 0.18.With SRF, the mean logRAD was 0.58 ± 0.32, whereas with IRF themean logRAD was measured at 0.70 ± 0.35.A SPED was associated with a mean logRAD score of 0.37 ± 0.10, aFPED was associated with 0.83 ± 0.26 and FPED with additional cystrevealed a mean logRAD score of 0.92 ± 0.28.Conclusions: In nAMD, a severe deficiency in reading acuity wasobserved especially with subfoveal NVC associated with additionalcysts and fibrovascular PED overlying cysts. Morphologic changes ofthe central retina have a direct impact on reading ability.Commercial Relationships: Florian Sulzbacher, None;Christopher G. Kiss, None; Stefan Sacu, None; Marion R. Munk,None; Alexandra Kaider, None; Tamara Mittermueller, None;Philipp K. Roberts, Canon Inc. (F); Ursula Schmidt-Erfurth,Alcon (C), Bayer Healthcare (C), Novartis (C)Program Number: 5032 Poster Board Number: A0194Presentation Time: 2:45 PM - 4:30 PMDark-adapted Microperimetry In Age-related Maculopathy AndGeographic AtrophyMichael D. Crossland 1, 2 , Rola Ba-Abbad 1, 2 , Simona Degli Esposti 2 ,Adnan Tufail 2, 3 , Gary S. Rubin 1, 3 . 1 UCL Institute of Ophthalmology,London, United Kingdom; 2 Moorfields Eye Hospital NHSFoundation Trust, London, United Kingdom; 3 NIHR MoorfieldsBiomedical Research Centre for Ophthalmology, London, UnitedKingdom.Purpose: In order to evaluate the effectiveness of emergingtreatments for geographic atrophy, responsive metrics of visualfunction are required. Histological, psychophysical and questionnairedata indicate reduced rod function in age-related maculopathy (ARM)and geographic atrophy (GA). In this study we use the new test ofdark-adapted microperimetry on a cohort of patients with ARM andGA to determine the effectiveness of this test on identifying areas ofretinal abnormality.Methods: 20 patients with ARM or GA were recruited. Conventionaland dark-adapted microperimetry were performed on a modifiedmicroperimeter (MP-1S, Nidek Technologies, Italy). Perimetry mapswere registered with autofluorescence images (obtained usingSpectralis, Heidelberg Engineering, Germany; superimposed usingNavis software (Nidek Technologies, Italy)). Areas of abnormality onthe autofluorescence image were identified by an ophthalmologistmasked to microperimetry results.Results: On average, more points were not seen at the highestintensity on dark-adapted than conventional microperimetry (meannumber of points missed: conventional: 4.45, dark-adapted: 12.2;matched pairs t-test, p
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