Visual Psychophysics / Physiological Optics - ARVO

ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group – Visual Psychophysics / Physiological Optics(p=0.021) and Reading index (p=0.020). IS/OS junction continuitywas associated with DVA (p=0.007), NVA (p=0.03) and SKILLscore (p=0.050). Photoreceptor layer continuity was associated withReading index (p=0.039). RPE layer continuity was associated withSKILL score (p=0.003).Conclusions: Significant associations exist between stressors ofmacular visual function such as near acuity and low luminance acuityand tomographic markers of retinal and choroidal morphology.Commercial Relationships: Ruth E. Hogg, Novartis (F), Novartis(C); George Murphy, None; Giovanni Staurenghi, OcularInstruments (P), GSK (C), Novartis (C), Alcon (C), Allergan (C),Bayer (C), Roche (C), Heidelberg Engineering (C), OD-OS (C), QLT(C), Optos (C); Chiara Rosina, None; Rufino Silva, Thea (C),Novartis (C), Bayer (C), Allergan (C), Alimera (C); Ana RitaSantos, None; Usha Chakravarthy, Bayer (C), Novartis (F),Neovista (C), Oraya (F)Program Number: 5029 Poster Board Number: A0191Presentation Time: 2:45 PM - 4:30 PMRelationship between retinal sensitivity and retinal thickness ineyes with retinal diseaseSrinivas R. Sadda, Muneeswar Nittala. Ophthalmology, Doheny EyeInstitute - USC, Los Angeles, CA.Purpose: To evaluate the point-to-point relationship between localretinal sensitivity as assessed by Optos SLO microperimetry andretinal thickness and volume as determined by optical coherencetomography (OCT).Methods: Twenty four eyes of twenty four subjects with variousretinal diseases were enrolled in this IRB-approved prospective crosssectional study. Microperimetry and spectral domain opticalcoherence tomography (SD-OCT) were obtained on the study eye ofall enrolled subjects using an Optos Spectral OCT/SLO (Optos plc,Dunfermline, UK). Microperimetry was performed with the using astandard 45 stimuli pattern spread over the central 12 degrees of themacula (foveal-centered), Goldmann III stimuli, and a 4-2-1threshold strategy. The OCT-derived retinal thickness map wasregistered to the microperimetry data by the OCT instrumentallowing point-to-point correlation between retinal sensitivity andOCT thickness. Correlation analysis was performed using a total of1080 loci.Results: The mean age of the study cohort was 69 (SD; 13) years and50 % were female. Retinal diseases in the study eyes included dryand wet age related macular degeneration, diabetic retinopathy, veinocclusions, macular telangiectasia and central serouschorioretinopathy. The mean baseline best-corrected (log MAR)visual acuity was 0.26 (Snellen ~ 20/30) and the mean (± SD) totalretinal sensitivity was 13.70 (± 2.74, range: 6.0 - 16.90) dB. The logMAR visual acuity was significantly correlated with mean retinalsensitivity (r= -0.43, p=0.05), with an expected stronger correlationfor foveal sensitivity (r= -0.74, p