Palliative Care Guidelines - NHS Lanarkshire

Palliative Care Guidelines: McKinley T34 syringe pump drug compatibility & stability chartsTable 3: Subcutaneous Oxycodone infusion in a McKinley T34 Syringe PumpDiluent: Water for injections• These are not clinical doses to prescribe. Most patients do not need such high doses.Read the relevant guidelines.• Use this table to check for concentrations that are stable.• Refer to the relevant guideline to obtain the usual dose range for each of the medications. Usethe minimum effective dose and titrate according to response.• The concentration of oxycodone injection is 10mg/ml. If the 24hour dose of oxycodoneexceeds 60mg, an alternative opioid may be needed for breakthough pain.Drug CombinationConcentrations of two drug combinations that arephysically stableOxycodoneCyclizineOxycodoneHaloperidolOxycodoneHyoscine butylbromideOxycodoneHyoscine hydrobromideOxycodoneKetorolacOxycodoneLevomepromazineOxycodoneMetoclopramideOxycodoneMidazolamOxycodoneOctreotide17ml in 20ml syringeDo not mix - Incompatible140mg10mg140mg40mg130mg1200 micrograms85mg30mg120mg100mg80mg40mg80mg40mg80mg400 micrograms22ml in 30ml syringeDo not mix - Incompatible180mg50mg100mg50mg100mg50mg100mg500 microgramsDrug CombinationConcentrations of three drug combinations that arephysically stableOxycodoneHaloperidolHyoscine butylbromideOxycodoneHaloperidolHyoscine hydrobromideOxycodoneHaloperidolMidazolamOxycodoneLevomepromazineHyoscine butylbromide17ml in 20ml syringe80mg2.5mg100mg80mg2.5mg1000 micrograms80mg2.5mg15mg80mg20mg100mg22ml in 30ml syringe100mg5mg120mg100mg5mg1200 micrograms100mg5mg20mg100mg25mg120mg© NHS Lanarkshire Issue date: January 2009 Review date: March 20123